Clinical diversity of sickle cell anemia: Genetic and cellular modulation of disease severity

Martin H. Steinberg, Robert P Hebbel

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

There is a great diversity in the clinical manifestations of sickle cell anemia. Some patients have severe repetitive infarctive episodes culminating in organ failure. Others have minor and nonincapacitating problems. This review focuses on the cellular and genetic factors that may play a role in modulating the clinical effects of the sickle hemoglobin gene. Understanding the role of putative modulators of disease severity may in the future allow the introduction of novel methods of therapy.

Original languageEnglish (US)
Pages (from-to)405-416
Number of pages12
JournalAmerican Journal of Hematology
Volume14
Issue number4
DOIs
StatePublished - Jun 1983

Keywords

  • hemoglobinopathy
  • sickle cell anemia

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