Clinical Corneal Confocal Microscopy

Auguste G.Y. Chiou, Stephen C. Kaufman, Herbert E. Kaufman, Roger W. Beuerman

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Confocal microscopy allows non-invasive in vivo imaging of the ocular surface. Its unique physical properties enable microscopic examination of all layers of the cornea and have been used to investigate numerous corneal diseases: epithelial changes, numerous stromal degenerative or dystrophic diseases, endothelial pathologies, corneal deposits, infections, and traumatic lesions. It offers a new approach to study the physiological reactions of the cornea to different stimuli and the pathophysiologic events leading to corneal dysfunction in certain diseases. Confocal microscopy proves to be a powerful diagnostic tool and is especially of value in certain corneal diseases by allowing straightforward and non-invasive recognition of the pathologic conditions.

Original languageEnglish (US)
Pages (from-to)482-500
Number of pages19
JournalSurvey of Ophthalmology
Issue number5
StatePublished - Sep 2006
Externally publishedYes

Bibliographical note

Copyright 2008 Elsevier B.V., All rights reserved.


  • confocal microscopy
  • cornea
  • in vivo microscopic examination


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