Clinical Characteristics and Inheritance of Idiopathic Epilepsy in Vizslas

Ned Patterson, James R Mickelson, Yang Da, Monica C. Roberts, Alistair S Mc Vey, Dennis P. O'Brien, Gary S. Johnson, P. Jane Armstrong

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Medical record, seizure survey, and telephone interview information was obtained for 29 Vizslas with idiopathic epilepsy (IE), 74 unaffected siblings, and 41 parents to determine the common clinical characteristics and most likely mode of inheritance. IE was diagnosed on the basis of the age of seizure onset, laboratory results, and neurologic examination findings. Computerized tomography (CT) or magnetic resonance imaging (MRI) scan with cerebrospinal fluid (CSF) analysis was required for the inclusion of dogs with an age of seizure onset of <6 months or >5 years. Simple segregation analysis was performed with an ascertainment correction and chi-square analysis. IE appeared to be familial in these pedigrees, with 79% of affected Vizslas exhibiting partial onset seizures. Partial seizure signs included a combination of limb tremors, staring, pupillary dilatation, or salivation without loss of consciousness in >50% of the dogs with partial signs. The estimated segregation frequency of P = .22 (95% CI, P = .08 to .36) was consistent with autosomal recessive inheritance; however, polygenic inheritance could not be excluded as a possibility. Simulated linkage with FASTSLINK estimated that the average logarithm of odds (LOD) score would be 3.23 with a 10-centimorgan (cM) whole-genome scan for these families, indicating that these families would be useful for a whole-genome scan to potentially find the chromosomal segment(s) containing the epilepsy gene or genes. We conclude that IE in Vizslas appears to be primarily a partial onset seizure disorder that may be inherited as an autosomal recessive trait.

Original languageEnglish (US)
Pages (from-to)319-325
Number of pages7
JournalJournal of veterinary internal medicine
Volume17
Issue number3
DOIs
StatePublished - May 1 2003

Keywords

  • Ascertainment correction
  • Partial seizures
  • Segregation analysis
  • Simulated linkage analysis

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