Clinical documentation of atherosclerotic plaque regression has been difficult to obtain. This is a report of a patient with severe and early atherosclerotic cardiovascular disease with regression of at least three major atherosclerotic lesions demonstrated by coronary arteriography 10 years after partial ileal bypass operation. The patient's total plasma cholesterol was reduced over these 10 years, ranging from 40% to 23%, from the preoperative level of 757 mg/dl. Sequential arteriograms were assessed independently by several arteriographers and blindly by the Arteriography Review Panel of the Program on Surgical Control of the Hyperlipidemias (POSCH). The readings were analyzed by 4 grading methods. Unanimously, marked regression was read in the proximal left circumflex artery (70% → 20%), middle segment of the right coronary artery (45% → 20%), and in the distal right coronary artery (80% → 50%). Thus, by any and all of the methods used, there was significant regression of arteriographically demonstrated atherosclerotic lesions.
Bibliographical noteFunding Information:
Supported by a grant from the National Heart, Lung. and Bloed Institute, HL-1 1901. and a Special Legislative Grant from the State of Minnesota. * Program on Surgical Control of the Hyperlipidemias (POSCH) Arteriography Review Panel: David Blankenhom, MD, Kurt Amplatz, MD. Joseph Bissett, MD, Wilfrido Castaneda, MD. MalcoIm Pearce. MD, Miguel Sanmarco, MD, Harry Sawin, MD. Reprint requests to: Henry Buchwald, MD, PhD, University of Minnesota Hospitals, Box 290 - Mayo, Minneapolis, MN 55455, U.S.A.
- Atherosclerotic lesion regression - Coronary arteriography - Partial ileal bypass - Plasma cholesterol and cholesterol fractions - POSCH Arteriography Review Panel