Clinical and biological concomitants of resting state EEG power abnormalities in schizophrenia

Scott R. Sponheim, Brett A. Clementz, William G. Iacono, Morton Beiser

Research output: Contribution to journalArticle

126 Scopus citations

Abstract

Background: This study investigated the clinical and biological concomitants of electroencephalogram power abnormalities in schizophrenia. Methods: We examined the power characteristics of resting electroencephalograms in 112 schizophrenic patients. Also collected were measures of psychotic symptomatology, brain morphology, ocular motor functioning, electrodermal activity, and nailfold plexus visibility. Seventy-eight nonschizophrenic psychosis patients (e.g., mood disorder patients with psychosis) and 107 nonpsychiatric control subjects were included for comparison. Results: Schizophrenic patients whose electroencephalograms were characterized by augmented low-frequency power and diminished alpha-band power had more negative symptoms, larger third ventricles, larger frontal horns of the lateral ventricles, increased cortical sulci widths, and greater ocular motor dysfunction compared with schizophrenic patients without these electroencephalogram characteristics. In nonschizophrenic psychosis patients, augmented low-frequency and diminished alpha-band powers failed to be associated with any clinical or biological indices. Conclusions: Results suggest that clinical and biological concomitants of low-frequency and alpha-band power abnormalities in schizophrenia are unique, perhaps indicating the presence of thalamic and frontal lobe dysfunction. (C) 2000 Society of Biological Psychiatry.

Original languageEnglish (US)
Pages (from-to)1088-1097
Number of pages10
JournalBiological psychiatry
Volume48
Issue number11
DOIs
StatePublished - Dec 1 2000

Keywords

  • Brain morphology
  • Electroencephalogram
  • Ocular motor function
  • Psychosis
  • Schizophrenia
  • Symptomatology

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