‘Click cyclic ADP-ribose’: a neutral second messenger mimic

Joanna M. Swarbrick; Richard Graeff; Clive Garnham; Mark P. Thomas; Antony Galione; Barry V.L. Potter

doi:10.1039/c3cc49249d

‘Click cyclic ADP-ribose’: a neutral second messenger mimic

Joanna M. Swarbrick, Richard Graeff, Clive Garnham, Mark P. Thomas, Antony Galione, Barry V.L. Potter

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Analogues of the potent Ca²⁺ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca²⁺ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators.

Original language	English (US)
Pages (from-to)	2458-2461
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	19
DOIs	https://doi.org/10.1039/c3cc49249d
State	Published - Feb 7 2014

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AU - Galione, Antony

AU - Potter, Barry V.L.

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AB - Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca2+ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators.

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‘Click cyclic ADP-ribose’: a neutral second messenger mimic

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