‘Click cyclic ADP-ribose’: a neutral second messenger mimic

Joanna M. Swarbrick, Richard Graeff, Clive Garnham, Mark P. Thomas, Antony Galione, Barry V.L. Potter

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca2+ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators.

Original languageEnglish (US)
Pages (from-to)2458-2461
Number of pages4
JournalChemical Communications
Issue number19
StatePublished - Feb 7 2014


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