‘Click cyclic ADP-ribose’: a neutral second messenger mimic

Joanna M. Swarbrick; Richard Graeff; Clive Garnham; Mark P. Thomas; Antony Galione; Barry V.L. Potter

doi:10.1039/c3cc49249d

‘Click cyclic ADP-ribose’: a neutral second messenger mimic

Joanna M. Swarbrick, Richard Graeff, Clive Garnham, Mark P. Thomas, Antony Galione, Barry V.L. Potter

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Analogues of the potent Ca²⁺ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca²⁺ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators.

Original language	English (US)
Pages (from-to)	2458-2461
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	19
DOIs	https://doi.org/10.1039/c3cc49249d
State	Published - Feb 7 2014

Publisher link

10.1039/c3cc49249d

Find It

Find It at U of M Libraries

Cite this

@article{27ce0d21663140d1ba93583bb2cffb65,

title = "{\textquoteleft}Click cyclic ADP-ribose{\textquoteright}: a neutral second messenger mimic",

abstract = "Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca2+ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators.",

author = "Swarbrick, {Joanna M.} and Richard Graeff and Clive Garnham and Thomas, {Mark P.} and Antony Galione and Potter, {Barry V.L.}",

year = "2014",

month = feb,

day = "7",

doi = "10.1039/c3cc49249d",

language = "English (US)",

volume = "50",

pages = "2458--2461",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "19",

}

TY - JOUR

T1 - ‘Click cyclic ADP-ribose’

T2 - a neutral second messenger mimic

AU - Swarbrick, Joanna M.

AU - Graeff, Richard

AU - Garnham, Clive

AU - Thomas, Mark P.

AU - Galione, Antony

AU - Potter, Barry V.L.

PY - 2014/2/7

Y1 - 2014/2/7

N2 - Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca2+ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators.

AB - Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca2+ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators.

UR - http://www.scopus.com/inward/record.url?scp=84893827216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893827216&partnerID=8YFLogxK

U2 - 10.1039/c3cc49249d

DO - 10.1039/c3cc49249d

M3 - Article

C2 - 24452494

AN - SCOPUS:84893827216

SN - 1359-7345

VL - 50

SP - 2458

EP - 2461

JO - Chemical Communications

JF - Chemical Communications

IS - 19

ER -

‘Click cyclic ADP-ribose’: a neutral second messenger mimic

Abstract

Publisher link

Find It

Other files and links

Fingerprint

Cite this