TY - JOUR
T1 - Classical and novel biomarkers for cardiovascular risk prediction in the United States
AU - Folsom, Aaron R.
PY - 2013
Y1 - 2013
N2 - Cardiovascular risk prediction models based on classical risk factors identified in epidemiologic cohort studies are useful in primary prevention of cardiovascular disease in individuals. This article briefly reviews aspects of cardiovascular risk prediction in the United States and efforts to evaluate novel risk factors. Even though many novel riskmarkers have been found to be associated with cardiovascular disease, few appear to improve risk prediction beyond the powerful, classical risk factors. A recent US consensus panel concluded that clinical measurement of certain novel markers for risk prediction was reasonable, namely, hemoglobin A1c (in all adults), microalbuminuria (in patients with hypertension or diabetes), and C-reactive protein, lipoprotein-associated phospholipase, coronary calcium, carotid intima-media thickness, and ankle/brachial index (in patients deemed to be at intermediate cardiovascular risk, based on traditional risk factors).
AB - Cardiovascular risk prediction models based on classical risk factors identified in epidemiologic cohort studies are useful in primary prevention of cardiovascular disease in individuals. This article briefly reviews aspects of cardiovascular risk prediction in the United States and efforts to evaluate novel risk factors. Even though many novel riskmarkers have been found to be associated with cardiovascular disease, few appear to improve risk prediction beyond the powerful, classical risk factors. A recent US consensus panel concluded that clinical measurement of certain novel markers for risk prediction was reasonable, namely, hemoglobin A1c (in all adults), microalbuminuria (in patients with hypertension or diabetes), and C-reactive protein, lipoprotein-associated phospholipase, coronary calcium, carotid intima-media thickness, and ankle/brachial index (in patients deemed to be at intermediate cardiovascular risk, based on traditional risk factors).
KW - Cardiovascular disease
KW - Coronary disease
KW - Epidemiology
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=84879912527&partnerID=8YFLogxK
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U2 - 10.2188/jea.JE20120157
DO - 10.2188/jea.JE20120157
M3 - Article
C2 - 23604062
AN - SCOPUS:84879912527
VL - 23
SP - 158
EP - 162
JO - Journal of Epidemiology
JF - Journal of Epidemiology
SN - 0917-5040
IS - 3
ER -