Class I alloantigen is sufficient for cytolytic T lymphocyte binding and transmembrane signaling

Kevin P. Kane, Steven A.N. Goldstein, Matthew F. Mescher

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Based largely on antibody blocking studies, a number of surface “accessory” molecules on effector cytolytic T lymphocytes (CTL) have been implicated as having a role in mediating CTL binding and lysis of target cells, possibly via binding to ligands on the target cell surface. Despite this, cloned allogeneic CTL were able to specifically bind cell‐size, artificial membranes (pseudocytes) bearing only class I alloantigen. This binding triggered CTL degranulation, as measured by serine esterase release. Thus, class I alloantigen alone is both a necessary and sufficient ligand for specific binding and effective transmembrane signaling to occur.

Original languageEnglish (US)
Pages (from-to)1925-1929
Number of pages5
JournalEuropean Journal of Immunology
Volume18
Issue number12
DOIs
StatePublished - Dec 1988

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