Cis-vaccenic acid and the Framingham risk score predict chronic kidney disease: The multi-ethnic study of atherosclerosis (MESA)

Robert Block, Lisa Kakinami, Scott Liebman, Gregory C. Shearer, Holly Kramer, Michael Tsai

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Introduction: Data on the associations of fatty acids with chronic kidney disease (CKD) are sparse. Materials and methods: We performed a cross-sectional study of 2792 men and women from the MESA cohort of African-American, Caucasian, Chinese and Hispanic adults without known cardiovascular disease. Plasma phospholipid fatty acid proportions were associated with estimated glomerular filtration rate (eGFR) and the albumin/creatinine ratio. Results: Cis-vaccenic acid (18:1. n-7), adjusted for other fatty acids using multivariate logistic regression (CI: 1.0-1.4), and step-wise logistic regression (CI: 1.02-1.42), was positively associated with reduced eGFR. The Framingham Risk Score, when adjusting for fatty acid proportions and demographic factors, was positively associated with CKD as measured by the eGFR and the albumin/creatinine ratio. Discussion and conclusions: Plasma phospholipid proportions of the 18 carbon monounsaturated cis-vaccenic acid {18:1. n-7}) and the Framingham Risk Score are associated with kidney function. The potential role of 18:1. n-7 in the development of CKD warrants further investigation.

Original languageEnglish (US)
Pages (from-to)175-182
Number of pages8
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume86
Issue number4-5
DOIs
StatePublished - Apr 2012

Bibliographical note

Funding Information:
Sources of Support . This research was supported by contracts N01-HC-95159 through N01-HC-95169 from the National Heart, Lung, and Blood Institute. The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org . This publication was also made possible by Grant Number KL2 RR 024136 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) and the NIH Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. Information on NCRR is available at http://www.ncrr.nih.gov/ . Information on Re-engineering the Clinical Research Enterprise can be obtained from http://nihroadmap.nih.gov/clinicalresearch/overview-translational.asp. Additional resources were provided by R01 HL071933 (S.G.), Reliant Pharmaceuticals and by NIH Grant (P20 RR016479) from the INBRE Program of the National Center for Research Resources.

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • 18:1n-7
  • Chronic kidney disease
  • Cis-vaccenic acid
  • Fatty acids
  • Framingham heart disease risk score
  • Monounsaturated 18 carbon fatty acid

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