cis-Dihydroxylation of olefins by a non-heme iron catalyst: A functional model for Rieske dioxygenases

Kui Chen, Que Lawrence

Research output: Contribution to journalArticle

149 Scopus citations

Abstract

The first iron complex capable of olefin cis-dihydroxylation in combination with H2O2 provides a functional model for Rieske dioxygenases. Mechanistic studies on the model reaction suggest the participation of an Fe(III)(η2-OOH) intermediate, with the oxygen atoms coming exclusively from H2O2 (see reaction scheme; L denotes a tris(6-methyl-2-pyridylmethyl)amine ligand, Solv = solvent). The similarities between the model and the enzymes strengthen the proposal that an Fe(III)- peroxo intermediate is involved in the enzymatic reactions.

Original languageEnglish (US)
Pages (from-to)2227-2229
Number of pages3
JournalAngewandte Chemie - International Edition
Volume38
Issue number15
DOIs
StatePublished - Aug 2 1999

Keywords

  • Dihydroxylations
  • Dioxygenases
  • Enzyme mimetics
  • Iron
  • Oxidations

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