Circulatory and platelet actions of 6,9-Thiaprostacyclin (PGI2-S) in the cat

Allan M. Lefer; George J. Trachte; J. Bryan Smith; William E. Barnette; K. C. Nicolaou

doi:10.1016/0024-3205(79)90293-5

Circulatory and platelet actions of 6,9-Thiaprostacyclin (PGI₂-S) in the cat

Allan M. Lefer
, George J. Trachte
, J. Bryan Smith
, William E. Barnette
, K. C. Nicolaou

Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A new analog of prostacyclin, 6,9-Thiaprostacyclin was infused intravenously in pentobarbital anesthetized cats in order to determine its hemodynamic and anti-platelet aggregating properties. At an infusion rate of 0.01 μmoles/kg/min, PGI₂-S moderately decreased arterial blood pressure without altering heart rate of superior mesenteric artery flow or platelet aggregation responses to ADP. However, at 0.05 μmoles/kg/min, PGI₂-S significantly reduced arterial blood pressure and significantly increased heart rate, and superior mesenteric artery flow. Moreover, at 0.05 μmoles/kg/min, PGI₂-S inhibited ADP platelet aggregation by 80%. PGI₂-S may be a useful agent in circulatory shock.

Original language	English (US)
Pages (from-to)	259-263
Number of pages	5
Journal	Life Sciences
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/0024-3205(79)90293-5
State	Published - Jul 16 1979

Bibliographical note

Funding Information:
Adult male cats (2.5 to 3.5 kg) were anesthetized with pentobarbital sodium (30 mg/kg) given intravenously. Supplemental anesthetic was given as Supported in part by NHLBI Institute Contract No . HO-E 2931 from the NIH and by the Ischemia-Shock Research Institute of Thomas Jefferson University .

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10.1016/0024-3205(79)90293-5

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@article{80a7375d47df4a5182668ad59c278ce1,

title = "Circulatory and platelet actions of 6,9-Thiaprostacyclin (PGI2-S) in the cat",

abstract = "A new analog of prostacyclin, 6,9-Thiaprostacyclin was infused intravenously in pentobarbital anesthetized cats in order to determine its hemodynamic and anti-platelet aggregating properties. At an infusion rate of 0.01 μmoles/kg/min, PGI2-S moderately decreased arterial blood pressure without altering heart rate of superior mesenteric artery flow or platelet aggregation responses to ADP. However, at 0.05 μmoles/kg/min, PGI2-S significantly reduced arterial blood pressure and significantly increased heart rate, and superior mesenteric artery flow. Moreover, at 0.05 μmoles/kg/min, PGI2-S inhibited ADP platelet aggregation by 80\%. PGI2-S may be a useful agent in circulatory shock.",

author = "Lefer, \{Allan M.\} and Trachte, \{George J.\} and \{Bryan Smith\}, J. and Barnette, \{William E.\} and Nicolaou, \{K. C.\}",

note = "Funding Information: Adult male cats (2.5 to 3.5 kg) were anesthetized with pentobarbital sodium (30 mg/kg) given intravenously. Supplemental anesthetic was given as Supported in part by NHLBI Institute Contract No . HO-E 2931 from the NIH and by the Ischemia-Shock Research Institute of Thomas Jefferson University .",

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T1 - Circulatory and platelet actions of 6,9-Thiaprostacyclin (PGI2-S) in the cat

AU - Lefer, Allan M.

AU - Trachte, George J.

AU - Bryan Smith, J.

AU - Barnette, William E.

AU - Nicolaou, K. C.

N1 - Funding Information: Adult male cats (2.5 to 3.5 kg) were anesthetized with pentobarbital sodium (30 mg/kg) given intravenously. Supplemental anesthetic was given as Supported in part by NHLBI Institute Contract No . HO-E 2931 from the NIH and by the Ischemia-Shock Research Institute of Thomas Jefferson University .

PY - 1979/7/16

Y1 - 1979/7/16

N2 - A new analog of prostacyclin, 6,9-Thiaprostacyclin was infused intravenously in pentobarbital anesthetized cats in order to determine its hemodynamic and anti-platelet aggregating properties. At an infusion rate of 0.01 μmoles/kg/min, PGI2-S moderately decreased arterial blood pressure without altering heart rate of superior mesenteric artery flow or platelet aggregation responses to ADP. However, at 0.05 μmoles/kg/min, PGI2-S significantly reduced arterial blood pressure and significantly increased heart rate, and superior mesenteric artery flow. Moreover, at 0.05 μmoles/kg/min, PGI2-S inhibited ADP platelet aggregation by 80%. PGI2-S may be a useful agent in circulatory shock.

AB - A new analog of prostacyclin, 6,9-Thiaprostacyclin was infused intravenously in pentobarbital anesthetized cats in order to determine its hemodynamic and anti-platelet aggregating properties. At an infusion rate of 0.01 μmoles/kg/min, PGI2-S moderately decreased arterial blood pressure without altering heart rate of superior mesenteric artery flow or platelet aggregation responses to ADP. However, at 0.05 μmoles/kg/min, PGI2-S significantly reduced arterial blood pressure and significantly increased heart rate, and superior mesenteric artery flow. Moreover, at 0.05 μmoles/kg/min, PGI2-S inhibited ADP platelet aggregation by 80%. PGI2-S may be a useful agent in circulatory shock.

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