Circulating carotenoid concentrations and incident hypertension

The Coronary Artery Risk Development in Young Adults (CARDIA) study

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

BACKGROUND: Several epidemiological studies have demonstrated that carotenoid concentrations relate inversely to cardiovascular disease incidence. Thus, we examined the association of circulating carotenoids with hypertension, a major macrovascular disease risk factor. METHODS: Black and White men and women in the Coronary Artery Risk Development in Young Adults Study, aged 18-30 years at recruitment (1985-1986) from four US cities, were investigated over 20 years. At years 0, 7, and 15, we determined the relationships of the sum of four serum carotenoids (±-carotene, ×-carotene, lutein/zeaxanthin, cryptoxanthin) and of lycopene with incident hypertension using proportional hazards regression models. RESULTS: In 4412 participants, year 0 sum of four carotenoids was significantly inversely associated with 20-year hypertension incidence after adjustment for baseline systolic blood pressure and other confounding factors (relative hazard per SD increase of sum of four carotenoids: 0.91; 95% confidence interval ≤ 0.84-0.99). The inverse relationships persisted in time-dependent models updating year 0 sum of four carotenoids with year 7 and year 15 values (relative hazard per SD increase of sum of four carotenoids: 0.84; 95% confidence interval ≤ 0.77-0.92). Lycopene was unrelated to hypertension in any model. CONCLUSION: Those individuals with higher concentrations of sum of carotenoids, not including lycopene, generally had lower risk for future hypertension.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalJournal of hypertension
Volume27
Issue number2
DOIs
StatePublished - Feb 1 2009

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Carotenoids
Young Adult
Coronary Vessels
Hypertension
Confidence Intervals
Blood Pressure
Lutein
Incidence
Proportional Hazards Models
Epidemiologic Studies
Cardiovascular Diseases
Serum
lycopene

Keywords

  • Antioxidant
  • Carotenoids
  • Epidemiology
  • Hypertension
  • Prospective studies

Cite this

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title = "Circulating carotenoid concentrations and incident hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) study",
abstract = "BACKGROUND: Several epidemiological studies have demonstrated that carotenoid concentrations relate inversely to cardiovascular disease incidence. Thus, we examined the association of circulating carotenoids with hypertension, a major macrovascular disease risk factor. METHODS: Black and White men and women in the Coronary Artery Risk Development in Young Adults Study, aged 18-30 years at recruitment (1985-1986) from four US cities, were investigated over 20 years. At years 0, 7, and 15, we determined the relationships of the sum of four serum carotenoids (±-carotene, ×-carotene, lutein/zeaxanthin, cryptoxanthin) and of lycopene with incident hypertension using proportional hazards regression models. RESULTS: In 4412 participants, year 0 sum of four carotenoids was significantly inversely associated with 20-year hypertension incidence after adjustment for baseline systolic blood pressure and other confounding factors (relative hazard per SD increase of sum of four carotenoids: 0.91; 95{\%} confidence interval ≤ 0.84-0.99). The inverse relationships persisted in time-dependent models updating year 0 sum of four carotenoids with year 7 and year 15 values (relative hazard per SD increase of sum of four carotenoids: 0.84; 95{\%} confidence interval ≤ 0.77-0.92). Lycopene was unrelated to hypertension in any model. CONCLUSION: Those individuals with higher concentrations of sum of carotenoids, not including lycopene, generally had lower risk for future hypertension.",
keywords = "Antioxidant, Carotenoids, Epidemiology, Hypertension, Prospective studies",
author = "Atsushi Hozawa and {Jacobs Jr}, {David R} and Steffes, {Michael W} and Gross, {Myron D} and Steffen, {Lyn M} and Lee, {Duk Hee}",
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T1 - Circulating carotenoid concentrations and incident hypertension

T2 - The Coronary Artery Risk Development in Young Adults (CARDIA) study

AU - Hozawa, Atsushi

AU - Jacobs Jr, David R

AU - Steffes, Michael W

AU - Gross, Myron D

AU - Steffen, Lyn M

AU - Lee, Duk Hee

PY - 2009/2/1

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N2 - BACKGROUND: Several epidemiological studies have demonstrated that carotenoid concentrations relate inversely to cardiovascular disease incidence. Thus, we examined the association of circulating carotenoids with hypertension, a major macrovascular disease risk factor. METHODS: Black and White men and women in the Coronary Artery Risk Development in Young Adults Study, aged 18-30 years at recruitment (1985-1986) from four US cities, were investigated over 20 years. At years 0, 7, and 15, we determined the relationships of the sum of four serum carotenoids (±-carotene, ×-carotene, lutein/zeaxanthin, cryptoxanthin) and of lycopene with incident hypertension using proportional hazards regression models. RESULTS: In 4412 participants, year 0 sum of four carotenoids was significantly inversely associated with 20-year hypertension incidence after adjustment for baseline systolic blood pressure and other confounding factors (relative hazard per SD increase of sum of four carotenoids: 0.91; 95% confidence interval ≤ 0.84-0.99). The inverse relationships persisted in time-dependent models updating year 0 sum of four carotenoids with year 7 and year 15 values (relative hazard per SD increase of sum of four carotenoids: 0.84; 95% confidence interval ≤ 0.77-0.92). Lycopene was unrelated to hypertension in any model. CONCLUSION: Those individuals with higher concentrations of sum of carotenoids, not including lycopene, generally had lower risk for future hypertension.

AB - BACKGROUND: Several epidemiological studies have demonstrated that carotenoid concentrations relate inversely to cardiovascular disease incidence. Thus, we examined the association of circulating carotenoids with hypertension, a major macrovascular disease risk factor. METHODS: Black and White men and women in the Coronary Artery Risk Development in Young Adults Study, aged 18-30 years at recruitment (1985-1986) from four US cities, were investigated over 20 years. At years 0, 7, and 15, we determined the relationships of the sum of four serum carotenoids (±-carotene, ×-carotene, lutein/zeaxanthin, cryptoxanthin) and of lycopene with incident hypertension using proportional hazards regression models. RESULTS: In 4412 participants, year 0 sum of four carotenoids was significantly inversely associated with 20-year hypertension incidence after adjustment for baseline systolic blood pressure and other confounding factors (relative hazard per SD increase of sum of four carotenoids: 0.91; 95% confidence interval ≤ 0.84-0.99). The inverse relationships persisted in time-dependent models updating year 0 sum of four carotenoids with year 7 and year 15 values (relative hazard per SD increase of sum of four carotenoids: 0.84; 95% confidence interval ≤ 0.77-0.92). Lycopene was unrelated to hypertension in any model. CONCLUSION: Those individuals with higher concentrations of sum of carotenoids, not including lycopene, generally had lower risk for future hypertension.

KW - Antioxidant

KW - Carotenoids

KW - Epidemiology

KW - Hypertension

KW - Prospective studies

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