TY - JOUR
T1 - Circulating Biomarkers and Abdominal Aortic Aneurysm Incidence
T2 - The Atherosclerosis Risk in Communities (ARIC) Study
AU - Folsom, Aaron R.
AU - Yao, Lu
AU - Alonso, Alvaro
AU - Lutsey, Pamela L.
AU - Missov, Emil
AU - Lederle, Frank A.
AU - Ballantyne, Christie M.
AU - Tang, Weihong
N1 - Publisher Copyright:
© 2015 American Heart Association, Inc.
PY - 2015/8/18
Y1 - 2015/8/18
N2 - Background - The pathogenesis of abdominal aortic aneurysm (AAA) is complex. Cross-sectional studies have connected circulating biomarkers with AAA, but prospective evidence is limited. Methods and Results - In the Atherosclerosis Risk in Communities Study cohort, we measured multiple blood biomarkers of inflammation, hemostasis, thrombin generation, cardiac dysfunction, and vascular stiffness and identified incident AAAs during follow-up using hospital discharge codes. Six biomarkers (white blood cell count, fibrinogen, D-dimer, troponin T, N-terminal pro-brain natriuretic peptide, and high-sensitivity C-reactive protein) were strongly associated positively with AAA incidence. Compared with having none of these 6 biomarkers in the highest quartile, the hazard ratios of AAA for those with 1, 2, 3, or 4 to 6 biomarkers in the highest quartile were 2.2, 3.3, 4.0, and 9.9, respectively (P for trend < 0.0001) after adjustment for other risk factors. Conclusions - This prospective study found that higher concentrations of 6 biomarkers were associated with increased risk of AAA. The more markers that fell into the highest quartile, the higher the AAA risk was. Multiple positive biomarkers identify a subgroup of patients at high risk of AAA.
AB - Background - The pathogenesis of abdominal aortic aneurysm (AAA) is complex. Cross-sectional studies have connected circulating biomarkers with AAA, but prospective evidence is limited. Methods and Results - In the Atherosclerosis Risk in Communities Study cohort, we measured multiple blood biomarkers of inflammation, hemostasis, thrombin generation, cardiac dysfunction, and vascular stiffness and identified incident AAAs during follow-up using hospital discharge codes. Six biomarkers (white blood cell count, fibrinogen, D-dimer, troponin T, N-terminal pro-brain natriuretic peptide, and high-sensitivity C-reactive protein) were strongly associated positively with AAA incidence. Compared with having none of these 6 biomarkers in the highest quartile, the hazard ratios of AAA for those with 1, 2, 3, or 4 to 6 biomarkers in the highest quartile were 2.2, 3.3, 4.0, and 9.9, respectively (P for trend < 0.0001) after adjustment for other risk factors. Conclusions - This prospective study found that higher concentrations of 6 biomarkers were associated with increased risk of AAA. The more markers that fell into the highest quartile, the higher the AAA risk was. Multiple positive biomarkers identify a subgroup of patients at high risk of AAA.
KW - aortic aneurysm, abdominal
KW - cohort studies
KW - risk factors
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U2 - 10.1161/CIRCULATIONAHA.115.016537
DO - 10.1161/CIRCULATIONAHA.115.016537
M3 - Article
C2 - 26085454
AN - SCOPUS:84939543290
VL - 132
SP - 578
EP - 585
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 7
ER -