Circular RNAs in Cardiovascular Disease: An Overview

Ximin Fan, Xinyu Weng, Yifan Zhao, Wei Chen, Tianyi Gan, Dachun Xu

Research output: Contribution to journalReview articlepeer-review

152 Scopus citations


Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in the regulation of gene expression, especially acting as miRNA sponges, and have described the potential mechanisms of several circRNAs in diseases, hinting at their clinical therapeutic values. In this review, the authors summarized the current understandings of the biogenesis and properties of circRNAs and their functions and role as biomarkers in cardiovascular diseases.

Original languageEnglish (US)
Article number5135781
JournalBioMed Research International
StatePublished - Jan 1 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Ximin Fan et al.


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