Circular RNAs in Cardiovascular Disease: An Overview

Ximin Fan, Xinyu Weng, Yifan Zhao, Wei Chen, Tianyi Gan, Dachun Xu

Research output: Contribution to journalReview article

66 Citations (Scopus)

Abstract

Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in the regulation of gene expression, especially acting as miRNA sponges, and have described the potential mechanisms of several circRNAs in diseases, hinting at their clinical therapeutic values. In this review, the authors summarized the current understandings of the biogenesis and properties of circRNAs and their functions and role as biomarkers in cardiovascular diseases.

Original languageEnglish (US)
Article number5135781
JournalBioMed Research International
Volume2017
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Untranslated RNA
Gene Expression Regulation
Porifera
MicroRNAs
Cardiovascular Diseases
Biomarkers
RNA
Research
Gene expression
Therapeutics
circular RNA

Cite this

Circular RNAs in Cardiovascular Disease : An Overview. / Fan, Ximin; Weng, Xinyu; Zhao, Yifan; Chen, Wei; Gan, Tianyi; Xu, Dachun.

In: BioMed Research International, Vol. 2017, 5135781, 01.01.2017.

Research output: Contribution to journalReview article

Fan, Ximin ; Weng, Xinyu ; Zhao, Yifan ; Chen, Wei ; Gan, Tianyi ; Xu, Dachun. / Circular RNAs in Cardiovascular Disease : An Overview. In: BioMed Research International. 2017 ; Vol. 2017.
@article{0f50999e2faf48f296334d1d8102f36d,
title = "Circular RNAs in Cardiovascular Disease: An Overview",
abstract = "Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in the regulation of gene expression, especially acting as miRNA sponges, and have described the potential mechanisms of several circRNAs in diseases, hinting at their clinical therapeutic values. In this review, the authors summarized the current understandings of the biogenesis and properties of circRNAs and their functions and role as biomarkers in cardiovascular diseases.",
author = "Ximin Fan and Xinyu Weng and Yifan Zhao and Wei Chen and Tianyi Gan and Dachun Xu",
year = "2017",
month = "1",
day = "1",
doi = "10.1155/2017/5135781",
language = "English (US)",
volume = "2017",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Circular RNAs in Cardiovascular Disease

T2 - An Overview

AU - Fan, Ximin

AU - Weng, Xinyu

AU - Zhao, Yifan

AU - Chen, Wei

AU - Gan, Tianyi

AU - Xu, Dachun

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in the regulation of gene expression, especially acting as miRNA sponges, and have described the potential mechanisms of several circRNAs in diseases, hinting at their clinical therapeutic values. In this review, the authors summarized the current understandings of the biogenesis and properties of circRNAs and their functions and role as biomarkers in cardiovascular diseases.

AB - Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in the regulation of gene expression, especially acting as miRNA sponges, and have described the potential mechanisms of several circRNAs in diseases, hinting at their clinical therapeutic values. In this review, the authors summarized the current understandings of the biogenesis and properties of circRNAs and their functions and role as biomarkers in cardiovascular diseases.

UR - http://www.scopus.com/inward/record.url?scp=85012231817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012231817&partnerID=8YFLogxK

U2 - 10.1155/2017/5135781

DO - 10.1155/2017/5135781

M3 - Review article

C2 - 28210621

AN - SCOPUS:85012231817

VL - 2017

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 5135781

ER -