Circuit-Based Corticostriatal Homologies Between Rat and Primate

Sarah R. Heilbronner, Jose Rodriguez-Romaguera, Gregory J. Quirk, Henk J. Groenewegen, Suzanne N. Haber

Research output: Contribution to journalArticlepeer-review

125 Scopus citations

Abstract

Background Understanding the neural mechanisms of psychiatric disorders requires the use of rodent models; however, frontal-striatal homologies between rodents and primates are unclear. In contrast, within the striatum, the shell of the nucleus accumbens, the hippocampal projection zone, and the amygdala projection zone (referred to as the striatal emotion processing network [EPN]) are conserved across species. We used the relationship between the EPN and projections from the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC) to assess network similarities across rats and monkeys. Methods We first compared the location and extent of each major component of the EPN in rats and macaques. Next, we used anatomic cases with anterograde injections in ACC/OFC to determine the extent to which corticostriatal terminal fields overlapped with these components and with each other. Results The location and size of each component of the EPN were similar across species, containing projections primarily from infralimbic cortex in rats and area 25 in monkeys. Other ACC/OFC terminals overlapped extensively with infralimbic cortex/area 25 projections, supporting cross-species similarities in OFC topography. However, dorsal ACC had different connectivity profiles across species. These results were used to segment the monkey and rat striata according to ACC/OFC inputs. Conclusions Based on connectivity with the EPN, and consistent with prior literature, the infralimbic cortex and area 25 are likely homologues. We also see evidence of OFC homologies. Along with segmenting the striatum and identifying striatal hubs of overlapping inputs, these results help to translate findings between rodent models and human pathology.

Original languageEnglish (US)
Pages (from-to)509-521
Number of pages13
JournalBiological psychiatry
Volume80
Issue number7
DOIs
StatePublished - Oct 1 2016

Bibliographical note

Funding Information:
This work was supported by Grant Nos. P50 MH086400, R01 MH045673, and P50 MH106435 (to SNH); R37 MH058883 (to GJQ); R36 MH105039 (to JRR); and F32 MH103931 (to SRH).

Keywords

  • Cingulate
  • Homology
  • Infralimbic
  • Orbitofrontal
  • Prefrontal
  • Prelimbic

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