Circuit and coil design for in-vitro magnetic neural stimulation systems

Eric Basham, Zhi Yang, Wentai Liu

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Magnetic stimulation of neural tissue is an attractive technology because neural excitation may be affected without requiring implantation of electrodes. Pulsed discharge circuits are typically implemented for clinical magnetic stimulation systems. However, pulsed discharge systems can confound in-vitro experimentation. As an alternative to pulsed discharge circuits, we present a circuit to deliver asymmetric current pulses forgeneration of the magnetic field. We scaled the system down by using ferrite cores for the excitation coil. The scaled system allows observation using electrophysiological techniques and preparations not commonly used for investigation of magnetic stimulation. The design was refined using a comprehensive set of design equations. Circuit modeling and simulation demonstrate that the proposed system is effective for stimulating neural tissue with electric-field gradients generated by time-varying magnetic fields. System performance is verified through electrical test. Copyright copy; 2009 IEEE.

Original languageEnglish (US)
Pages (from-to)321-331
Number of pages11
JournalIEEE transactions on biomedical circuits and systems
Issue number5
StatePublished - Oct 2009

Bibliographical note

Funding Information:
Manuscript received July 12, 2008; revised January 21, 2009. Current version published September 25, 2009. This work was supported in part by the National Science Foundation Biomimetic MicroElectronic Systems Research Center under Agreement No. H31512, Amendment 6, and in part by National Semiconductor, Santa Clara, CA. This paper was recommended by Associate Editor R. Genov.


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