Circaoctohoran (about 8-hourly) chronome component of circulating human endothelin-1 in health

A. Loeckinger, M. Herold, G. Cornelissen, F. Halberg, B. Fiser

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Endothelin-1 (ET-1) is a very potent vasoconstrictor. A study of 72 subjects sampled every 4 hours for 24 hours failed to reveal a circadian variation for ET-1, but an about-half-weekly component, assessed transversely, was found for ET-1. As a follow-up, plasma ET-1 was measured around the clock at 20-min intervals for 24 hours on a clinically healthy man, 27 years of age, while atriopeptin (AP) was determined on every fourth sample (at 80-min intervals). An about-8-hour component suspected but not assessable in the larger study is validated, whereas a circadian is demonstrated for atriopeptin. The different circaoctohoran versus circadian prominent frequencies of two related hormones suggest the operation of multiple mechanisms in circulatory coordination, rather than a master circadian oscillator.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
JournalScripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
Issue number4
StatePublished - Dec 1 1998


  • Chronobiology
  • Circadian variability
  • Endotelin-1


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