Circadian rhythms of plasma renin activity and aldosterone: Changes related to age, sex, recumbency and sodium restriction. Chronobiologic specification for reference values

Pietro Cugini, Giulia Murano, Piernatale Lucia, Claudio Letizia, Domenico Scavo, Franz Halberg, Germaine Cornelissen, Robert B. Sothern

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Plasma renin activity (PRA) and aldosterone (PA) levels are characterized by a circadian rhythmicity (CR). The present study revealed that this rhythmicity is influenced by several factors including posture, sodium intake and age. Time-qualified PRA and PA reference intervals can reduce the incidence of false positives and false negatives in a diagnostic work-up. The circadian rhythmicity of PRA and PA have been quantified in relation to posture, sodium intake and age. The cosinor procedure has been applied to quantify the properties of the circadian rhythmicity under these conditions. Chronograms and circadian parameters can be used to optimize the use of PRA and PA measurements in clinical practice. The chronobiological specification of reference values for PRA and PA is of valuable importance since the assessment of PRA and PA circadian rhythmicity has a diagnostic interest for a certain type of clinical disorder. It should be noted that several studies have described circannual variations for renin and aldosterone. The next step in the optimation of laboratory time-qualified reference values is the assessment of changes induced by the deterministic factors on a circannual domain.

Original languageEnglish (US)
Pages (from-to)267-276
Number of pages10
JournalChronobiology international
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1985

Keywords

  • Aldosterone
  • Angiotensin
  • Circadian rhythm
  • Cosinor
  • Hypertension
  • Renin

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