Circadian rhythm of sister chromatid exchanges in human chromosomes

V. Goywes, A. Cupeiro, A. Campos, B. Lage, L. Garcia Alonso, Germaine G Cornelissen-Guillaume, F. Halberg

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Since sister chromatid exchange (SCE) relates directly to DNA synthesis which is circadian periodic, this study examines whether a circadian rhythm also characterizes SCEs. In 4-hourly blood samples collected for 48 hours on three diurnally active, nocturnally resting subjects with no family history of chromosome aberrations or instability, a circadian rhythm is demonstrable with an acrophase occuring around 14:45. The circadian amplitude is only of the older of 10% of the MESOR in untreated cultures or in cultures exposed to cefodizime. It remains more or less unchanged in cultures exposed to mitomycin-C, while the MESOR increases by about a factor of 2. In studies of human chromosome aberrations, the circadian rhythmicity of SCE should be taken into consideration.

Original languageEnglish (US)
Pages (from-to)413-415
Number of pages3
JournalIn Vivo
Issue number4
StatePublished - 1995

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  • Circadian rhythm
  • Human chromosomes
  • Sister chromatic exchanges


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