Circadian regulation in tissue regeneration

Ellen Paatela, Dane Munson, Nobuaki Kikyo

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Circadian rhythms regulate over 40% of protein-coding genes in at least one organ in the body through mechanisms tied to the central circadian clock and to cell-intrinsic auto-regulatory feedback loops. Distinct diurnal differences in regulation of regeneration have been found in several organs, including skin, intestinal, and hematopoietic systems. Each regenerating system contains a complex network of cell types with different circadian mechanisms contributing to regeneration. In this review, we elucidate circadian regeneration mechanisms in the three representative systems. We also suggest circadian regulation of global translational activity as an understudied global regulator of regenerative capacity. A more detailed understanding of the molecular mechanisms underlying circadian regulation of tissue regeneration would accelerate the development of new regenerative therapies.

Original languageEnglish (US)
Article number2263
JournalInternational journal of molecular sciences
Issue number9
StatePublished - May 1 2019

Bibliographical note

Funding Information:
Funding: The works related to this article have been supported by the NIH (R01 GM098294, R21 AR066158, R21 HD083648, and R21 CA187232), Regenerative Medicine Minnesota (RMM 101617 DS 004), and Engdahl Family Foundation.

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.


  • Circadian rhythms
  • Hematopoiesis
  • Intestine
  • Ribosome biogenesis
  • Skin
  • Tissue regeneration


Dive into the research topics of 'Circadian regulation in tissue regeneration'. Together they form a unique fingerprint.

Cite this