Circadian reference values for different endpoints of heart rate variability

Kuniaki Otsuka, Germaine G Cornelissen-Guillaume, M. Shinagawa, Y. Nishimura, Y. Kubo, N. Hotta, C. Fujii, T. Ishii, K. Omori, Y. Watanabe, S. Nunoda, S. Ohkawa, F. Halberg

Research output: Contribution to journalConference articlepeer-review

5 Scopus citations


While it is known that endpoints of HRV undergo a circadian variation, time-specified reference value ranges are lacking. To fill this void, peer-group reference standards are presented. They are derived on the basis of data from 219 healthy males in 8 age groups: 5-10 years, 10-20 years, 20-30 years, 30-40 years, 40-50 years, 50-60 years, 60-70 years and >70 years, and from 117 healthy females in 4 age groups: <20 years, 20-40 years, 40-60 years, and >60 years. The spectral Q component (Q for quadrisecundan, rather than `HF') and the D/Q ratio (D for decisecundan, rather than `LF/HF') were computed hourly for 24 hours. Time-specified reference limits (chronodesms) were computed for each variable in each group as 90% prediction limits. Circadian chronodesms in different age groups indicate that both Q and D/Q vary greatly as a function of age. Chronodesms here proposed may serve for evaluating risk and the efficacy of various interventions.

Original languageEnglish (US)
Pages (from-to)587-590
Number of pages4
JournalComputers in Cardiology
StatePublished - 1999
EventThe 26th Annual Meeting: Computers in Cardiology 1999 - Hannover, Ger
Duration: Sep 26 1999Sep 29 1999


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