Circadian periodicity and effect of gender, age, diet and smoking on circulating plasma lipid peroxides and antioxidant enzymes in healthy Indians of different age groups

Ranjana Singh, Abbas Ali Mahdi, Raj Kumar Singh, Kuniaki Otsuka, Cathy Lee Gierke, Germaine G Cornelissen-Guillaume

Research output: Contribution to journalArticle

Abstract

This study aims at assessing circadian rhythm characteristics of oxidants and antioxidants, testing for any effect of gender, age, diet and smoking status. Blood samples from clinically healthy Indians (103 males and 59 females, 7–75 years of age) were collected at 6-hour intervals for 24 hours for determination of MDA, SOD, CAT, GPx and GR. Data were analyzed by the single and population-mean cosinor to estimate circadian rhythm characteristics. The latter were further analyzed by multi-factor analysis of variance. A marked circadian rhythm was documented for all variables. Its parameters were found to undergo marked changes as a function of age. Males differed from females in terms of the rhythm-adjusted mean (MESOR) of CAT and GPx and of the 24-hour amplitude of GR. The MESOR of GPx differed between vegetarians and omnivores. Smoking status affected the MESOR of MDA and CAT and the 24-hour amplitude of CAT. As oxidative stress is being reported for most diseases, the mapping of circadian rhythms in oxidant and antioxidant enzymes in health may help refine reference values, thereby allowing the early detection of pathophysiological conditions, prompting the early institution of treatment. Abbreviations: CAT: Catalase; FRAP: Ferric Reducing Antioxidant Power; GPx: Glutathione Peroxidase; GR: Glutathione Reductase; GSH: Glutathione; MDA: Malondialdehyde; MESOR: Midline Estimating Statistic Of Rhythm; ROS: Reactive Oxygen Species; SCN: Suprachiasmatic Nuclei; SOD: Superoxide Dismutase; TBARs: Thiobarbituric acid reactive substances; XPA: Xeroderma Pigmentosum, Complementation Group A (DNA Damage Recognition And Repair Factor).

Original languageEnglish (US)
JournalBiological Rhythm Research
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

circadian rhythm
Lipid Peroxides
smoking (food products)
Periodicity
Circadian Rhythm
peroxides
smoking
periodicity
blood lipids
antioxidant
gender
Age Groups
Antioxidants
Smoking
lipid
enzyme
diet
Diet
antioxidants
plasma

Keywords

  • Age
  • catalase (CAT)
  • circadian
  • glutathione peroxidase (GPx)
  • glutathione reductase (GR)
  • health
  • malondialdehyde (MDA)
  • reactive oxygen species (ROS)
  • superoxide dismutase (SOD)

Cite this

Circadian periodicity and effect of gender, age, diet and smoking on circulating plasma lipid peroxides and antioxidant enzymes in healthy Indians of different age groups. / Singh, Ranjana; Mahdi, Abbas Ali; Singh, Raj Kumar; Otsuka, Kuniaki; Lee Gierke, Cathy; Cornelissen-Guillaume, Germaine G.

In: Biological Rhythm Research, 01.01.2019.

Research output: Contribution to journalArticle

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abstract = "This study aims at assessing circadian rhythm characteristics of oxidants and antioxidants, testing for any effect of gender, age, diet and smoking status. Blood samples from clinically healthy Indians (103 males and 59 females, 7–75 years of age) were collected at 6-hour intervals for 24 hours for determination of MDA, SOD, CAT, GPx and GR. Data were analyzed by the single and population-mean cosinor to estimate circadian rhythm characteristics. The latter were further analyzed by multi-factor analysis of variance. A marked circadian rhythm was documented for all variables. Its parameters were found to undergo marked changes as a function of age. Males differed from females in terms of the rhythm-adjusted mean (MESOR) of CAT and GPx and of the 24-hour amplitude of GR. The MESOR of GPx differed between vegetarians and omnivores. Smoking status affected the MESOR of MDA and CAT and the 24-hour amplitude of CAT. As oxidative stress is being reported for most diseases, the mapping of circadian rhythms in oxidant and antioxidant enzymes in health may help refine reference values, thereby allowing the early detection of pathophysiological conditions, prompting the early institution of treatment. Abbreviations: CAT: Catalase; FRAP: Ferric Reducing Antioxidant Power; GPx: Glutathione Peroxidase; GR: Glutathione Reductase; GSH: Glutathione; MDA: Malondialdehyde; MESOR: Midline Estimating Statistic Of Rhythm; ROS: Reactive Oxygen Species; SCN: Suprachiasmatic Nuclei; SOD: Superoxide Dismutase; TBARs: Thiobarbituric acid reactive substances; XPA: Xeroderma Pigmentosum, Complementation Group A (DNA Damage Recognition And Repair Factor).",
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AU - Lee Gierke, Cathy

AU - Cornelissen-Guillaume, Germaine G

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