Circadian period of human blood pressure and heart rate in clinical health under ordinary conditions

Kuniaki Otsuka, Germaine Cornelissen, Noubar Aslanian, Biba Helou, Haruo Watanabe, James E. Holte, Franz Halberg

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Putative point-and-interval estimates of the circadian period τ of cardiovascular variables were obtained from 95 clinically healthy nurses who measured their blood pressure and heart rate about every 15 minutes for 48 hours in November or June, using a Colin Medical Instruments ABPM-630 ambulatory monitor. Linear-nonlinear least-squares rhythmometry yields estimates of the circadian period, with a single-component (24-h cosine curve) and a two-component (24- and 12-h cosine curves) model. For systolic blood pressure, in an individualized fashion, analysis based on a single 24-h component allows the determination of the circadian period with 95% confidence limits in all but three of the 95 series. On a population average, 95% confidence intervals bracket anticipated periods of 24 and 12 h; but on an individualized basis, the 95% confidence interval of τ does not cover precisely 24 h in almost 50% of the cases. A reference standard is provided for the assessment by linear-nonlinear rhythmometry of circadian cardiovascular periods under usual conditions of life with a 48-h record.

Original languageEnglish (US)
Title of host publicationProc Second Ann IEEE Symp Comput Based Med Syst
Editors Anon
PublisherPubl by IEEE
Pages206-213
Number of pages8
StatePublished - Dec 1 1989
EventProceedings: Second Annual IEEE Symposium on Computer-Based Medical Systems - Minneapolis, MN, USA
Duration: Jun 26 1989Jun 27 1989

Other

OtherProceedings: Second Annual IEEE Symposium on Computer-Based Medical Systems
CityMinneapolis, MN, USA
Period6/26/896/27/89

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