Circadian disruption and Vascular Variability Disorders (VVD): Mechanisms linking aging, disease state and Arctic shift-work: Applications for chronotherapy

D. G. Gubin, G. Cornelissen, D. Weinert, A. S. Vetoshkin, L. I. Gapon, N. P. Shurkevich, F. A. Poshinov, N. V. Belozerova, L. A. Danilova

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

A fast growing body of evidence indicates that the circadian system is important for health. In turn, desynchrony has been associated with the development of numerous agerelated diseases and the aging process. Alterations of the circadian variation occurring within the physiological range provide warning signs that, if acted upon, lead to truly primary prevention not across the board but targeted to the individual person. This is the case for instance for Vascular Variability Disorders. Particular attention is given to blood pressure and heart rate recorded in the elderly, in shiftworkers in the Arctic, and to a personalized chronotherapeutic approach.

Original languageEnglish (US)
Pages (from-to)285-306
Number of pages22
JournalWorld Heart Journal
Volume5
Issue number4
StatePublished - Apr 2013

Keywords

  • Aging
  • Arctic
  • Blood pressure
  • Chronotherapy
  • Circadian rhythms
  • Heart rate
  • Hypertension
  • Melatonin
  • Variability

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