Circadian blood pressure overswinging in a physically fit, normotensive African American woman

Katarina T. Borer; Germaine G Cornelissen-Guillaume; Franz Halberg; Robert Brook; Sanjay Rajagopalan; William Fay

doi:10.1016/S0895-7061(02)02973-4

Circadian blood pressure overswinging in a physically fit, normotensive African American woman

Katarina T. Borer, Germaine G Cornelissen-Guillaume, Franz Halberg, Robert Brook, Sanjay Rajagopalan, William Fay

Physiology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Ambulatory blood pressure (BP) and heart rate (HR) were measured in a physically fit, normotensive postmenopausal African American woman, before and after 15 weeks of aerobic training. Mean BP, HR, and HR variability were normal at the outset and were further improved by training. Training had no effect on circadian BP variation, which exceeded gender- and age-specified limits, indicative of circadian hyperamplitude tension (CHAT). A 12-week treatment with the β₁-adrenoceptor blocker atenolol, 14 months post-training, normalized CHAT and HR variability and further reduced BP and HR. These results suggest β₁-adrenergic mediation of CHAT and its refractoriness to exercise training.

Original language	English (US)
Pages (from-to)	827-830
Number of pages	4
Journal	American journal of hypertension
Volume	15
Issue number	9
DOIs	https://doi.org/10.1016/S0895-7061(02)02973-4
State	Published - Sep 2002

Bibliographical note

Funding Information:
Support for this work was provided by National Institutes of Health grant M01-RR00042 to the University of Michigan General Clinical Research Center, and by the Michigan Initiative for Women’s Health.

Keywords

And blood pressure variability
Exercise
Heart rate
Hypertension
Risk factors
Stroke

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10.1016/S0895-7061(02)02973-4

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title = "Circadian blood pressure overswinging in a physically fit, normotensive African American woman",

abstract = "Ambulatory blood pressure (BP) and heart rate (HR) were measured in a physically fit, normotensive postmenopausal African American woman, before and after 15 weeks of aerobic training. Mean BP, HR, and HR variability were normal at the outset and were further improved by training. Training had no effect on circadian BP variation, which exceeded gender- and age-specified limits, indicative of circadian hyperamplitude tension (CHAT). A 12-week treatment with the β1-adrenoceptor blocker atenolol, 14 months post-training, normalized CHAT and HR variability and further reduced BP and HR. These results suggest β1-adrenergic mediation of CHAT and its refractoriness to exercise training.",

keywords = "And blood pressure variability, Exercise, Heart rate, Hypertension, Risk factors, Stroke",

author = "Borer, {Katarina T.} and Cornelissen-Guillaume, {Germaine G} and Franz Halberg and Robert Brook and Sanjay Rajagopalan and William Fay",

note = "Funding Information: Support for this work was provided by National Institutes of Health grant M01-RR00042 to the University of Michigan General Clinical Research Center, and by the Michigan Initiative for Women{\textquoteright}s Health. ",

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AU - Borer, Katarina T.

AU - Cornelissen-Guillaume, Germaine G

AU - Halberg, Franz

AU - Brook, Robert

AU - Rajagopalan, Sanjay

AU - Fay, William

N1 - Funding Information: Support for this work was provided by National Institutes of Health grant M01-RR00042 to the University of Michigan General Clinical Research Center, and by the Michigan Initiative for Women’s Health.

PY - 2002/9

Y1 - 2002/9

N2 - Ambulatory blood pressure (BP) and heart rate (HR) were measured in a physically fit, normotensive postmenopausal African American woman, before and after 15 weeks of aerobic training. Mean BP, HR, and HR variability were normal at the outset and were further improved by training. Training had no effect on circadian BP variation, which exceeded gender- and age-specified limits, indicative of circadian hyperamplitude tension (CHAT). A 12-week treatment with the β1-adrenoceptor blocker atenolol, 14 months post-training, normalized CHAT and HR variability and further reduced BP and HR. These results suggest β1-adrenergic mediation of CHAT and its refractoriness to exercise training.

AB - Ambulatory blood pressure (BP) and heart rate (HR) were measured in a physically fit, normotensive postmenopausal African American woman, before and after 15 weeks of aerobic training. Mean BP, HR, and HR variability were normal at the outset and were further improved by training. Training had no effect on circadian BP variation, which exceeded gender- and age-specified limits, indicative of circadian hyperamplitude tension (CHAT). A 12-week treatment with the β1-adrenoceptor blocker atenolol, 14 months post-training, normalized CHAT and HR variability and further reduced BP and HR. These results suggest β1-adrenergic mediation of CHAT and its refractoriness to exercise training.

KW - And blood pressure variability

KW - Exercise

KW - Heart rate

KW - Hypertension

KW - Risk factors

KW - Stroke

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Circadian blood pressure overswinging in a physically fit, normotensive African American woman

Abstract

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