Ambulatory blood pressure (BP) and heart rate (HR) were measured in a physically fit, normotensive postmenopausal African American woman, before and after 15 weeks of aerobic training. Mean BP, HR, and HR variability were normal at the outset and were further improved by training. Training had no effect on circadian BP variation, which exceeded gender- and age-specified limits, indicative of circadian hyperamplitude tension (CHAT). A 12-week treatment with the β1-adrenoceptor blocker atenolol, 14 months post-training, normalized CHAT and HR variability and further reduced BP and HR. These results suggest β1-adrenergic mediation of CHAT and its refractoriness to exercise training.
Bibliographical noteFunding Information:
Support for this work was provided by National Institutes of Health grant M01-RR00042 to the University of Michigan General Clinical Research Center, and by the Michigan Initiative for Women’s Health.
Copyright 2008 Elsevier B.V., All rights reserved.
- And blood pressure variability
- Heart rate
- Risk factors