Circadian blood pressure overswinging in a physically fit, normotensive African American woman

Katarina T. Borer, Germaine G Cornelissen-Guillaume, Franz Halberg, Robert Brook, Sanjay Rajagopalan, William Fay

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Ambulatory blood pressure (BP) and heart rate (HR) were measured in a physically fit, normotensive postmenopausal African American woman, before and after 15 weeks of aerobic training. Mean BP, HR, and HR variability were normal at the outset and were further improved by training. Training had no effect on circadian BP variation, which exceeded gender- and age-specified limits, indicative of circadian hyperamplitude tension (CHAT). A 12-week treatment with the β1-adrenoceptor blocker atenolol, 14 months post-training, normalized CHAT and HR variability and further reduced BP and HR. These results suggest β1-adrenergic mediation of CHAT and its refractoriness to exercise training.

Original languageEnglish (US)
Pages (from-to)827-830
Number of pages4
JournalAmerican journal of hypertension
Issue number9
StatePublished - Sep 2002

Bibliographical note

Funding Information:
Support for this work was provided by National Institutes of Health grant M01-RR00042 to the University of Michigan General Clinical Research Center, and by the Michigan Initiative for Women’s Health.


  • And blood pressure variability
  • Exercise
  • Heart rate
  • Hypertension
  • Risk factors
  • Stroke


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