CinQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo

Keyphrases

• Growth in Vitro 100%
• Allosteric Kinase Inhibitor 100%
• Mitogen-activated Protein Kinase 100%
• Cancer Growth 100%
• Cancer Cell Growth 66%
• MEK Inhibitor (MEKi) 66%
• Therapeutic Target 33%
• Tumor 33%
• MEK1 33%
• Signaling Pathway 33%
• Chemotherapy 33%
• Inhibitor Development 33%
• Tumorigenesis 33%
• Anchorage 33%
• Kinase Activity 33%
• Major Components 33%
• Highly Effective 33%
• Inhibitory Activity 33%
• Fibrosarcoma 33%
• Colon Cancer Cells 33%
• ERK Phosphorylation 33%
• Activating mutation 33%
• Anchorage-independent Cell Growth 33%
• Extracellular Signal-regulated Kinase Signaling 33%
• Rat Sarcoma 33%
• MEK2 33%
• KRAS Oncogene 33%
• Xenograft Mouse Model 33%
• S6 Kinase 1 (S6K1) 33%
• ERK Extracellular Signal-regulated Kinase 33%
• Skin Toxicity 33%
• BRAF Oncogene 33%
• Signaling Axis 33%

Medicine and Dentistry

• In Vitro 100%
• Cancer Growth 100%
• MEK Inhibitor 100%
• Kinase Signaling 66%
• Anchorage 66%
• Mitogen-Activated Protein Kinase 66%
• Malignant Neoplasm 33%
• Cell Growth 33%
• Chemotherapy 33%
• Phosphotransferase 33%
• Neoplasm 33%
• Xenograft 33%
• Carcinogenesis 33%
• Oncogene 33%
• Fibrosarcoma 33%
• Mitogen Activated Protein Kinase Kinase 33%
• S6 Kinase 33%
• Colon Carcinoma 33%
• Mitogen Activated Protein Kinase Kinase 1 33%
• Skin Toxicity 33%
• Mitogen Activated Protein Kinase Kinase 2 33%
• Signal Transduction 33%
• Connective Tissue Cancer 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Mitogen Activated Protein Kinase Kinase Inhibitor 100%
• Cancer Growth 100%
• Mitogen Activated Protein Kinase 66%
• Chemotherapy 33%
• Mouse Model 33%
• Malignant Neoplasm 33%
• Phosphotransferase 33%
• Fibrosarcoma 33%
• S6 Kinase 33%
• Mitogen Activated Protein Kinase Kinase 33%
• Colon Carcinoma 33%
• Mitogen Activated Protein Kinase Kinase 1 33%
• Skin Toxicity 33%
• Mitogen Activated Protein Kinase Kinase 2 33%
• Neoplasm 33%
• Carcinogenesis 33%
• Connective Tissue Cancer 33%