Cigarette smoking and dementia: Potential selection bias in the elderly

Miguel A. Hernán, Alvaro Alonso, Giancarlo Logroscino

Research output: Contribution to journalComment/debate

85 Scopus citations

Abstract

We conducted a systematic review of published prospective studies that estimated the association between smoking and the incidence of Alzheimer disease and dementia. The relative rate for smokers versus nonsmokers ranged from 0.27 to 2.72 for Alzheimer disease (12 studies) and from 0.38 to 1.42 for dementia (6 studies). The minimum age at entry (range: 55-75 years) explained much of the between-study heterogeneity in relative rates. We conjecture that selection bias due to censoring by death may be the main explanation for the reversal of the relative rate with increasing age.

Original languageEnglish (US)
Pages (from-to)448-450
Number of pages3
JournalEpidemiology
Volume19
Issue number3
DOIs
StatePublished - May 1 2008

Fingerprint Dive into the research topics of 'Cigarette smoking and dementia: Potential selection bias in the elderly'. Together they form a unique fingerprint.

  • Cite this