TY - JOUR
T1 - Cigarette smoking, alcohol consumption, and risk of ARDS
T2 - A 15-year cohort study in a managed care setting
AU - Iribarren, Carlos
AU - Jacobs, David R.
AU - Sidney, Stephen
AU - Gross, Myron D.
AU - Eisner, Mark D.
N1 - Funding Information:
This study was supported by contract RO1-AG-12264–01A1 from the National Institute on Aging, National Institutes of Health, Bethesda, MD.
PY - 2000
Y1 - 2000
N2 - Study objective: To examine the association of cigarette smoking and alcohol consumption with hospital presentation of ARDS in a well-defined, multiethnic population. Design: Retrospective cohort study. Setting: Health maintenance organization in Northern California. Participants: A total of 121,012 health plan subscribers (54.2% women), aged 25 to 89 years. Outcome measure: Hospital presentation of ARDS (validated by medical chart review) from baseline in 1979 to 1985 through the end of 1993 (median, 9.9 years). Results: There were 56 cases of ARDS (33 in men, 23 in women). The case fatality rate was 39% in both genders. ARDS was independently related to increasing age (rate ratio of 10 years, 1.38; 95% confidence interval [CI], 1.12 to 1.71), to current smoking of < 20 cigarettes/d (rate ratio vs never cigarette smokers, 2.85; 95% CI, 1.23 to 6.60), and to current cigarette smoking of ≥ 20 cigarettes/d (rate ratio vs never smokers, 4.59; 95% CI, 2,13 to 9.88). No association was observed between alcohol consumption and ARDS. Conclusions: The results of this study suggest a relationship (with evidence of dose-response effect) between cigarette smoking and ARDS. Assuming a causal relationship, approximately 50% of ARDS cases were attributable to cigarette smoking.
AB - Study objective: To examine the association of cigarette smoking and alcohol consumption with hospital presentation of ARDS in a well-defined, multiethnic population. Design: Retrospective cohort study. Setting: Health maintenance organization in Northern California. Participants: A total of 121,012 health plan subscribers (54.2% women), aged 25 to 89 years. Outcome measure: Hospital presentation of ARDS (validated by medical chart review) from baseline in 1979 to 1985 through the end of 1993 (median, 9.9 years). Results: There were 56 cases of ARDS (33 in men, 23 in women). The case fatality rate was 39% in both genders. ARDS was independently related to increasing age (rate ratio of 10 years, 1.38; 95% confidence interval [CI], 1.12 to 1.71), to current smoking of < 20 cigarettes/d (rate ratio vs never cigarette smokers, 2.85; 95% CI, 1.23 to 6.60), and to current cigarette smoking of ≥ 20 cigarettes/d (rate ratio vs never smokers, 4.59; 95% CI, 2,13 to 9.88). No association was observed between alcohol consumption and ARDS. Conclusions: The results of this study suggest a relationship (with evidence of dose-response effect) between cigarette smoking and ARDS. Assuming a causal relationship, approximately 50% of ARDS cases were attributable to cigarette smoking.
KW - ARDS
KW - Alcohol
KW - Epidemiology
KW - Risk factors
KW - Smoking
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U2 - 10.1378/chest.117.1.163
DO - 10.1378/chest.117.1.163
M3 - Article
C2 - 10631215
AN - SCOPUS:0033957613
SN - 0012-3692
VL - 117
SP - 163
EP - 168
JO - Diseases of the chest
JF - Diseases of the chest
IS - 1
ER -