Cigarette smoke inhalation potentiates elastase-induced emphysema in hamsters

J. R. Hoidal, Dennis E Niewoehner

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Cigarette smoke is shown, in this study, to potentiate emphysema induced by intratracheal administration of elastase, whereas elastase alone caused minimal disease. Elastase-treated hamsters with prior or ongoing smoke exposure uniformly had severe emphysema with decreases in lung elastic recoil and increases in mean linear intercept (L(m)). In contrast, hamsters receiving elastase alone, cigarette smoke alone, or postelastase cigarette smoke developed no or barely detectable histopathologic evidence of emphysema. Lungs from these animals had normal elastic recoil and L(m). These data support the idea that cigarette smoke exposure may unmask or amplify protease-induced emphysema caused by acute lung injury.

Original languageEnglish (US)
Pages (from-to)478-481
Number of pages4
JournalAmerican Review of Respiratory Disease
Volume127
Issue number4
DOIs
StatePublished - 1983

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