Cigarette smoke-elastase interactions in the pathogenesis of emphysema

D. E. Niewoehner, J. R. Hoidal

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The results support the concept that prior or coexistent cigarette smoke exposure might modify protease-induced lung injury from some other cause to result in emphysema. Possible mechanisms for this effect include: oxidative inactivation of alpha1-antiproteinase directly by cigarette smoke or indirectly via smoke-induced recruitment of lung phagocytes; increased protease levels from smoke-recruited phagocytes; cigarette smoke-induced defects in lung repair; or other smoke-induced alterations in lung structure or function which enhance susceptibility to protease damage.

Original languageEnglish (US)
Pages (from-to)62S-63S
Issue number5 Suppl.
StatePublished - 1983


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