Chrosomal organization of the human major histocompatibility complex class I gene family

B. H. Koller, D. E. Geraghty, R. DeMars, L. Duvick, S. S. Rich, H. T. Orr

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

17 HLA class I genes have been isolated from the genome of B-lymphoblastoid cell line 721. Sequence analysis and transfection studies indicate that three genes, in addition to those encoding the HLA-A, -B, and -C antigens can direct the synthesis of a class I α protein. Using gene-specific DNA probes to analyze the presence of restriction fragment-length polymorphisms within a large pedigree and in panel of HLA deletion mutant cell lines, we show that two of these genes, designated HLA-G and HLA-F, are lcoated on the short arm of chromosome 6 telomeric to the HLA-A locus. The third expressed non-A, -B, and -C class I gene, HLA-E, is located between HLA-A and HLA-C. In addition, the remaining 11 class I pseudogenes and gene fragments are localized relative to established markers on chromosome 6p.

Original languageEnglish (US)
Pages (from-to)469-480
Number of pages12
JournalJournal of Experimental Medicine
Volume169
Issue number2
DOIs
StatePublished - Jan 1 1989

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