Chronopharmacologic individualized and group assessment of outcomes in antihypertensive drug trials

Franz Halberg, Germaine G Cornelissen-Guillaume, Jinyi Wu, Prince K. Zachariah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

15 Scopus citations

Abstract

Chronobiologic methods are illustrated for the individualized assessment of the patient's response to antihypertensive medication. In addition to the 24-h mean from blood pressure profiles obtained by ambulatory monitoring, specific endpoints serve as gauges of treatment efficacy. These endpoints include the circadian amplitude, a measure of predictable extent of change within 24 h, and hyperbaric (or hypertensive) indices of excess or load. The latter indices assess the duration and amount of blood pressure excess by comparison to critical thresholds. In view of the large circadian variation characterizing blood pressure, the usual time-invariant limits of 140/90 mm Hg (systolic/diastolic) are replaced by time-specified 90% prediction limits derived from data of clinically healthy peers.

Original languageEnglish (US)
Title of host publicationProc Second Ann IEEE Symp Comput Based Med Syst
Editors Anon
PublisherPubl by IEEE
Pages253-259
Number of pages7
StatePublished - Dec 1 1989
EventProceedings: Second Annual IEEE Symposium on Computer-Based Medical Systems - Minneapolis, MN, USA
Duration: Jun 26 1989Jun 27 1989

Other

OtherProceedings: Second Annual IEEE Symposium on Computer-Based Medical Systems
CityMinneapolis, MN, USA
Period6/26/896/27/89

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