TY - JOUR
T1 - Chronomics
T2 - Circadian and circaseptan timing of radiotherapy, drugs, calories, perhaps nutriceuticals and beyond
AU - Halberg, Franz
AU - Cornélissen, Germaine
AU - Wang, Zhengrong
AU - Wan, Chaomin
AU - Ulmer, Waldemar
AU - Katinas, George
AU - Singh, Ranjana
AU - Singh, R. K.
AU - Singh, Rajesh Kumar
AU - Gupta, B. D.
AU - Singh, R. B.
AU - Kumar, Adarsh
AU - Kanabrocki, Eugene
AU - Sothern, Robert B.
AU - Rao, Gundu
AU - Bhatt, Madan L B
AU - Srivastava, Madhu
AU - Rai, Gulshan
AU - Singh, Subhash
AU - Pati, Atanu Kumar
AU - Nath, Panchanan
AU - Halberg, Francine
AU - Halberg, Julia
AU - Schwartzkopff, Othild
AU - Bakken, Earl
AU - Shastri, Shri Vishnu Kant
PY - 2003/9
Y1 - 2003/9
N2 - We suggest a putative benefit from timing nutriceuticals (substances that are both nutrients and pharmaceuticals) such as antioxidants for preventive or curative health care, based on the proven merits of timing nutrients, drugs, and other treatments, as documented, i.a., in India. The necessity of timing melatonin, a major antioxidant, is noted. A protocol to extend the scope of chronoradiotherapy awaits testing. Imaging in time by mapping rhythms and broader time structures, chronomes, for earliest diagnoses, for example detection of vascular disease risk, is recommended. The study of rhythms and broader chronomes leads to a dynamic functional genomics, guided by imaging in time of free radicals and antioxidants, amongst many other variables.
AB - We suggest a putative benefit from timing nutriceuticals (substances that are both nutrients and pharmaceuticals) such as antioxidants for preventive or curative health care, based on the proven merits of timing nutrients, drugs, and other treatments, as documented, i.a., in India. The necessity of timing melatonin, a major antioxidant, is noted. A protocol to extend the scope of chronoradiotherapy awaits testing. Imaging in time by mapping rhythms and broader time structures, chronomes, for earliest diagnoses, for example detection of vascular disease risk, is recommended. The study of rhythms and broader chronomes leads to a dynamic functional genomics, guided by imaging in time of free radicals and antioxidants, amongst many other variables.
KW - Chronome
KW - Chronomics
KW - Chronotherapy
KW - Circadian
KW - Circaseptan
KW - Nutriceuticals
UR - http://www.scopus.com/inward/record.url?scp=0346363808&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0346363808&partnerID=8YFLogxK
U2 - 10.1111/j.1533-869X.2003.01097.x
DO - 10.1111/j.1533-869X.2003.01097.x
M3 - Review article
C2 - 14641812
AN - SCOPUS:0346363808
SN - 1359-4117
VL - 3
SP - 223
EP - 260
JO - Journal of Experimental Therapeutics and Oncology
JF - Journal of Experimental Therapeutics and Oncology
IS - 5
ER -