Chronome of urinary 6-sulfoxy-melatonin excretion, circulating CA125, cancer progression and therapeutic response

Germaine G Cornelissen-Guillaume; H. Berg; E. Haus; F. Halberg

Chronome of urinary 6-sulfoxy-melatonin excretion, circulating CA125, cancer progression and therapeutic response

Germaine G Cornelissen-Guillaume, H. Berg, E. Haus, F. Halberg

Physiology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The longitudinal follow-up of a patient with an advanced adenocarcinoma of the ovary sheds new light on the involvement of the pineal in carcinogenesis. The changes in the circadian MESOR of 6-sulfoxy-melatonin following a course of chemotherapy may differ in relation to the success of failure of treatment, yet the MESOR does not correlate with tumor burden assessed by circulating CA125. By contrast, the ratio of circaseptan-to-circadian amplitudes involving two chronome components correlates with the cancer marker. To that extent, the study reveals a critical about 7-day (circaseptan) aspect of the pineal involvement in cancer progression. This information could be exploited in designing schedules of melatonin administration to cancer patients.

Original language	English (US)
Pages (from-to)	375-378
Number of pages	4
Journal	In Vivo
Volume	9
Issue number	4
State	Published - Sep 22 1995

Keywords

Chronome
Circaseptan
Melatonin

Access

Fingerprint Dive into the research topics of 'Chronome of urinary 6-sulfoxy-melatonin excretion, circulating CA125, cancer progression and therapeutic response'. Together they form a unique fingerprint.

Cite this

@article{2cf67a5fa84f43a1a5522b8222c813ee,

title = "Chronome of urinary 6-sulfoxy-melatonin excretion, circulating CA125, cancer progression and therapeutic response",

abstract = "The longitudinal follow-up of a patient with an advanced adenocarcinoma of the ovary sheds new light on the involvement of the pineal in carcinogenesis. The changes in the circadian MESOR of 6-sulfoxy-melatonin following a course of chemotherapy may differ in relation to the success of failure of treatment, yet the MESOR does not correlate with tumor burden assessed by circulating CA125. By contrast, the ratio of circaseptan-to-circadian amplitudes involving two chronome components correlates with the cancer marker. To that extent, the study reveals a critical about 7-day (circaseptan) aspect of the pineal involvement in cancer progression. This information could be exploited in designing schedules of melatonin administration to cancer patients.",

keywords = "Chronome, Circaseptan, Melatonin",

author = "Cornelissen-Guillaume, {Germaine G} and H. Berg and E. Haus and F. Halberg",

year = "1995",

month = sep,

day = "22",

language = "English (US)",

volume = "9",

pages = "375--378",

journal = "In Vivo",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

number = "4",

}

TY - JOUR

T1 - Chronome of urinary 6-sulfoxy-melatonin excretion, circulating CA125, cancer progression and therapeutic response

AU - Cornelissen-Guillaume, Germaine G

AU - Berg, H.

AU - Haus, E.

AU - Halberg, F.

PY - 1995/9/22

Y1 - 1995/9/22

N2 - The longitudinal follow-up of a patient with an advanced adenocarcinoma of the ovary sheds new light on the involvement of the pineal in carcinogenesis. The changes in the circadian MESOR of 6-sulfoxy-melatonin following a course of chemotherapy may differ in relation to the success of failure of treatment, yet the MESOR does not correlate with tumor burden assessed by circulating CA125. By contrast, the ratio of circaseptan-to-circadian amplitudes involving two chronome components correlates with the cancer marker. To that extent, the study reveals a critical about 7-day (circaseptan) aspect of the pineal involvement in cancer progression. This information could be exploited in designing schedules of melatonin administration to cancer patients.

AB - The longitudinal follow-up of a patient with an advanced adenocarcinoma of the ovary sheds new light on the involvement of the pineal in carcinogenesis. The changes in the circadian MESOR of 6-sulfoxy-melatonin following a course of chemotherapy may differ in relation to the success of failure of treatment, yet the MESOR does not correlate with tumor burden assessed by circulating CA125. By contrast, the ratio of circaseptan-to-circadian amplitudes involving two chronome components correlates with the cancer marker. To that extent, the study reveals a critical about 7-day (circaseptan) aspect of the pineal involvement in cancer progression. This information could be exploited in designing schedules of melatonin administration to cancer patients.

KW - Chronome

KW - Circaseptan

KW - Melatonin

UR - http://www.scopus.com/inward/record.url?scp=0029102902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029102902&partnerID=8YFLogxK

M3 - Article

C2 - 8555437

AN - SCOPUS:0029102902

VL - 9

SP - 375

EP - 378

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 4

ER -