Chronoecoepidemiology of "strain": Infradian chronomics of urinary cortisol and catecholamines during nightly exposure to noise

Christian Maschke, Jan Harder, Germaine G Cornelissen-Guillaume, Karl Hecht, Kuniaki Otsuka, Franz Halberg

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


This meta-analysis of published data (Noise Health 5 (2002) 35 and 47) summarizing a survey for 40 days of the nightly excretion of urinary free cortisol, epinephrine and norepinephrine validates a circaseptan cortisol pattern anticipated and reported earlier for cortisol, here not detected for the catecholamines. We also quantify a circadecan (about 10-day) variation in nightly norepinephrine excretion, but not in the excretion of the other two hormones examined. About 4.2-day variations, common to norepinephrine and epinephrine, and an about 4.7-day variation in cortisol await further scrutiny, since these components were not anticipated. Infradian characteristics are quantified time-microscopically and differences among infradian aspects of the spectral element of endocrine chronomes (time structures; from chronos, time and nomos, rule) are demonstrated. Chronomics, the cartography of chronomes, reveals that "stress hormones" need to be examined separately in a budding chronoepidemiology seeking to detect how humans interact, mostly for better, sometimes for worse, with the undesirable features of the technology they create and of its consequences, such as aircraft noise.

Original languageEnglish (US)
Pages (from-to)126-135
Number of pages10
JournalBiomedicine and Pharmacotherapy
Issue numberSUPPL. 1
StatePublished - Oct 2003


  • Aircraft noise
  • Chronome
  • Circaseptan (biologic week)
  • Steroid metabolism
  • Strain
  • Stress


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