Chronobiology's progress. Part II, chronomics for an immediately applicable biomedicine

Franz Halberg, Germaine G Cornelissen-Guillaume, George Katinas, Levan Tvildiani, Marina Gigolashvili, Ketevan Janashia, Tim Toba, Miguel Revilla, Philip Regal, Robert B. Sothern, Hans W. Wendt, Zhengrong Wang, Michal Zeman, Rita Jozsa, R. B. Singh, Gen Mitsutake, Sergei M. Chibisov, Jong Lee, Dan Holley, James E. HolteRobert P. Sonkowsky, Othild Schwartzkopff, Patrick Delmore, Kuniaki Otsuka, Earl E. Bakken, Jerzy Czaplicki

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Chronomic cardiovascular surveillance serves to recognise and treat any risk elevation as well as overt disease, and to ascertain whether treatment is effective and, if so, for how long treatment effects lasts, be it for lowering an increased risk and/or in surveilling the success or failure of treatment. A treatment-associated increase in circadian amplitude of blood pressure (BP) may induce iatrogenic overswinging, also dubbed CHAT (circadian hyper-amplitude-tension), in some patients, thereby increasing cardiovascular disease risk unknowingly to care provider and receiver.

Original languageEnglish (US)
Pages (from-to)73-86
Number of pages14
JournalJournal of Applied Biomedicine
Issue number2
StatePublished - Jun 2006


  • Blood pressure surveillance
  • CHAT
  • Chronobioethics
  • Food restriction
  • Health care


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