Chronobiology of high blood pressure

Germaine G Cornelissen-Guillaume, F. Halberg, E. E. Bakken, Z. Wang, R. Tarquini, F. Perfetto, G. Laffi, G. Maggioni, Y. Kumagai, P. Homolka, A. Havelková, J. Dušek, H. Svačinová, J. Siegelová, B. Fišer

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


BIOCOS, the project aimed at studying BIOlogical systems in their COSmos, has obtained a great deal of expertise in the fields of blood pressure (BP) and heart rate (HR) monitoring and of marker rhythmometry for the purposes of screening, diagnosis, treatment, and prognosis. Prolonging the monitoring reduces the uncertainty in the estimation of circadian parameters; the current recommendation of BIOCOS requires monitoring for at least 7 days. The BIOCOS approach consists of a parametric and a non-parametric analysis of the data, in which the results from the individual subject are being compared with gender- and age-specified reference values in health. Chronobiological designs can offer important new information regarding the optimization of treatment by timing its administration as a function of circadian and other rhythms. New technological developments are needed to close the loop between the monitoring of blood pressure and the administration of antihypertensive drugs.

Original languageEnglish (US)
Pages (from-to)157-166
Number of pages10
JournalScripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
Issue number4
StatePublished - 2007


  • 7-day ambulatory blood pressure monitoring
  • Chronobiological approach
  • High blood pressure


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