Chronobiologic aspects of urinary gonadotropin peptide (UGP)

Germaine G Cornelissen-Guillaume, F. Halberg, R. Walker, R. M. Zaslavskaya, R. L. Fine, E. Haus

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


When using urinary gonadotropin peptide (UGP) as a marker for ovarian cancer, a circadian rhythm of large amplitude is best assessed for improving preanalytic quality control, for specifying how often and when to sample and resolving chronobiologic endpoints. In a patient (EH, 73 y) with an ovarian (Mullerian) adenocarcinoma, overall high UGP values occurred consistently around 07:00 (standard deviation, SD=2 h), similar to the timing observed in a presumably healthy woman. The circadian rhythm of EH averages in amplitude about 45% of the daily mean value (SD=15%). The results indicate the desirability of deriving time-specified reference limits in health for an improved diagnostic value of UGP. The circadian on UGP pattern awaits tests of applications for a chronodiagnosis of ovarian cancer, for optimizing treatment efficacy by timing according to rhythms, and conceivably for detecting earliest pre-cancer risk.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalIn Vivo
Issue number4
StatePublished - 1995

Bibliographical note

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  • Circadian
  • Ovarian cancer
  • Urinary gonadotropin peptide (UGP)


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