Chronic vagus nerve stimulation for treatment-resistant depression decreases resting ventromedial prefrontal glucose metabolism

José V. Pardo, Sohail A. Sheikh, Graeme C. Schwindt, Joel T. Lee, Michael A. Kuskowski, Christa Surerus, Scott M. Lewis, Faruk S. Abuzzahab, David E. Adson, Barry R. Rittberg

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Vagus nerve stimulation (VNS) is used as an adjunctive therapy for treatment-resistant depression (TRD). Its mechanism of action is not fully understood. Longitudinal measurement of changes in brain metabolism associated with VNS can provide insights into this new treatment modality. Eight severely depressed outpatients who were highly treatment-resistant underwent electrical stimulation of the left vagus nerve for approximately one year. The main outcome measures were resting regional brain glucose uptake measured with positron emission tomography (PET) and the 24-item Hamilton Depression Scale. The most significant and extensive change over one year of chronic VNS localized to the ventromedial prefrontal cortex extending from the subgenual cingulate to the frontal pole. This region continued to decline in metabolism even toward the end of the study. Clinically, this cohort showed a trend for improvement. No correlations surfaced between change in glucose uptake and depression scores. However, the sample size was small; none remitted; and the range of depression scores was limited. Chronic VNS as adjunctive therapy in patients with severe TRD produces protracted and robust declines in resting brain activity within the ventromedial prefrontal cortex, a network with dense connectivity to the amygdala and structures monitoring the internal milieu.

Original languageEnglish (US)
Pages (from-to)879-889
Number of pages11
JournalNeuroImage
Volume42
Issue number2
DOIs
StatePublished - Aug 15 2008

Keywords

  • Amygdala
  • Computed tomography
  • Deep brain stimulation (DBS)
  • Default-mode
  • Electroconvulsive therapy (ECT)
  • Emission (PET)
  • Emotion
  • Functional magnetic resonance imaging (fMRI)
  • Glucose metabolism
  • Neuromodulation
  • Nucleus accumbens
  • Pleasure
  • Subgenual anterior cingulate
  • Treatment-resistant depression
  • Ventromedial prefrontal cortex (VMPFC)

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