Chronic thalamic stimulation for the tremor of multiple sclerosis

Erwin B. Montgomery, Kenneth B. Baker, R. Philip Kinkel, Gene Barnett

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


The authors studied chronic high-frequency stimulation of the ventral intermediate nucleus of the thalamus (Vim) for controlling upper extremity tremor in patients with MS using MRI, CT, and microelectrode recordings and stimulation to locate optimal target sites. Fifteen patients underwent surgery. All patients had reduced tremor but developed tolerance requiring repeated programming of the stimulator. Benefit at optimal stimulator settings was maintained. Two patients experienced complications: intracerebral hematoma and MS exacerbation. Chronic high-frequency stimulation of Vim provides tremor reduction if patients have access to frequent stimulator adjustments. This surgery is relatively safe.

Original languageEnglish (US)
Pages (from-to)625-628
Number of pages4
Issue number3
StatePublished - Aug 11 1999
Externally publishedYes


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