Chronic psychosocial stress down-regulates central cytokines mRNA

Alessandro Bartolomucci; Paola Palanza; Stefano Parmigiani; Tiziana Pederzani; Elodie Merlot; Pierre J. Neveu; Robert Dantzer

doi:10.1016/j.brainresbull.2003.09.009

Chronic psychosocial stress down-regulates central cytokines mRNA

Alessandro Bartolomucci, Paola Palanza, Stefano Parmigiani, Tiziana Pederzani, Elodie Merlot, Pierre J. Neveu, Robert Dantzer

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Brain cytokines have been implicated in brain plasticity and mood alterations. We present here the first evidence of a chronic stress-induced modulation of central cytokines, in absence of experimentally induced inflammatory processes. Several brain areas were extracted from stressed and control mice and cytokines mRNA analyzed with semi-quantitative RT-PCR. Mice subjected to chronic psychosocial stress showed decreased interleukin (IL)-1β mRNA levels in the hippocampus, decreased IL-1Receptor antagonist in the striatum and pituitary, decreased tumor necrosis factor (TNF)-α in the striatum and hippocampus, and decreased glucocorticoid receptor (GR) in the striatum and hippocampus compared to group housed sibling mice. An independent group of mice subjected to chronic psychosocial stress also showed increased plasma corticosterone. These findings may open new perspectives for understanding the pathophysiological basis of chronic stress-induced disorders.

Original language	English (US)
Pages (from-to)	173-178
Number of pages	6
Journal	Brain Research Bulletin
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/j.brainresbull.2003.09.009
State	Published - Dec 30 2003
Externally published	Yes

Bibliographical note

Funding Information:
Supported by Italian MURST (COFIN 2000) and University of Parma (FIN 2000-01) and DGA (agreement no. 00.34.060.00.470.75.01). Authors wish to thank all the colleagues of the U394-INSERM of Bordeaux, and in particular J. Arsaut, G. Hebert, J.P. Konsman, E. Moze, for their kind help provided in several phases of the present study. V. Vascelli is acknowledged for technical assistance.

Keywords

Corticosterone
Glucocorticoid receptors
Hippocampus
IL-1β
Striatum
TNF-α

Publisher link

10.1016/j.brainresbull.2003.09.009

Find It

Find It at U of M Libraries

Cite this

@article{55237bdb6b534f65b42d9a36c6f4190c,

title = "Chronic psychosocial stress down-regulates central cytokines mRNA",

abstract = "Brain cytokines have been implicated in brain plasticity and mood alterations. We present here the first evidence of a chronic stress-induced modulation of central cytokines, in absence of experimentally induced inflammatory processes. Several brain areas were extracted from stressed and control mice and cytokines mRNA analyzed with semi-quantitative RT-PCR. Mice subjected to chronic psychosocial stress showed decreased interleukin (IL)-1β mRNA levels in the hippocampus, decreased IL-1Receptor antagonist in the striatum and pituitary, decreased tumor necrosis factor (TNF)-α in the striatum and hippocampus, and decreased glucocorticoid receptor (GR) in the striatum and hippocampus compared to group housed sibling mice. An independent group of mice subjected to chronic psychosocial stress also showed increased plasma corticosterone. These findings may open new perspectives for understanding the pathophysiological basis of chronic stress-induced disorders.",

keywords = "Corticosterone, Glucocorticoid receptors, Hippocampus, IL-1β, Striatum, TNF-α",

author = "Alessandro Bartolomucci and Paola Palanza and Stefano Parmigiani and Tiziana Pederzani and Elodie Merlot and Neveu, {Pierre J.} and Robert Dantzer",

note = "Funding Information: Supported by Italian MURST (COFIN 2000) and University of Parma (FIN 2000-01) and DGA (agreement no. 00.34.060.00.470.75.01). Authors wish to thank all the colleagues of the U394-INSERM of Bordeaux, and in particular J. Arsaut, G. Hebert, J.P. Konsman, E. Moze, for their kind help provided in several phases of the present study. V. Vascelli is acknowledged for technical assistance.",

year = "2003",

month = dec,

day = "30",

doi = "10.1016/j.brainresbull.2003.09.009",

language = "English (US)",

volume = "62",

pages = "173--178",

journal = "Brain Research Bulletin",

issn = "0361-9230",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Chronic psychosocial stress down-regulates central cytokines mRNA

AU - Bartolomucci, Alessandro

AU - Palanza, Paola

AU - Parmigiani, Stefano

AU - Pederzani, Tiziana

AU - Merlot, Elodie

AU - Neveu, Pierre J.

AU - Dantzer, Robert

N1 - Funding Information: Supported by Italian MURST (COFIN 2000) and University of Parma (FIN 2000-01) and DGA (agreement no. 00.34.060.00.470.75.01). Authors wish to thank all the colleagues of the U394-INSERM of Bordeaux, and in particular J. Arsaut, G. Hebert, J.P. Konsman, E. Moze, for their kind help provided in several phases of the present study. V. Vascelli is acknowledged for technical assistance.

PY - 2003/12/30

Y1 - 2003/12/30

N2 - Brain cytokines have been implicated in brain plasticity and mood alterations. We present here the first evidence of a chronic stress-induced modulation of central cytokines, in absence of experimentally induced inflammatory processes. Several brain areas were extracted from stressed and control mice and cytokines mRNA analyzed with semi-quantitative RT-PCR. Mice subjected to chronic psychosocial stress showed decreased interleukin (IL)-1β mRNA levels in the hippocampus, decreased IL-1Receptor antagonist in the striatum and pituitary, decreased tumor necrosis factor (TNF)-α in the striatum and hippocampus, and decreased glucocorticoid receptor (GR) in the striatum and hippocampus compared to group housed sibling mice. An independent group of mice subjected to chronic psychosocial stress also showed increased plasma corticosterone. These findings may open new perspectives for understanding the pathophysiological basis of chronic stress-induced disorders.

AB - Brain cytokines have been implicated in brain plasticity and mood alterations. We present here the first evidence of a chronic stress-induced modulation of central cytokines, in absence of experimentally induced inflammatory processes. Several brain areas were extracted from stressed and control mice and cytokines mRNA analyzed with semi-quantitative RT-PCR. Mice subjected to chronic psychosocial stress showed decreased interleukin (IL)-1β mRNA levels in the hippocampus, decreased IL-1Receptor antagonist in the striatum and pituitary, decreased tumor necrosis factor (TNF)-α in the striatum and hippocampus, and decreased glucocorticoid receptor (GR) in the striatum and hippocampus compared to group housed sibling mice. An independent group of mice subjected to chronic psychosocial stress also showed increased plasma corticosterone. These findings may open new perspectives for understanding the pathophysiological basis of chronic stress-induced disorders.

KW - Corticosterone

KW - Glucocorticoid receptors

KW - Hippocampus

KW - IL-1β

KW - Striatum

KW - TNF-α

UR - http://www.scopus.com/inward/record.url?scp=0347753521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347753521&partnerID=8YFLogxK

U2 - 10.1016/j.brainresbull.2003.09.009

DO - 10.1016/j.brainresbull.2003.09.009

M3 - Article

C2 - 14698350

AN - SCOPUS:0347753521

SN - 0361-9230

VL - 62

SP - 173

EP - 178

JO - Brain Research Bulletin

JF - Brain Research Bulletin

IS - 3

ER -

Chronic psychosocial stress down-regulates central cytokines mRNA

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this