Chronic myeloid leukemia

Kapil Bhalla, Celalettin Ustun, Warren Fiskus

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

It is estimated that 4,870 new cases of chronic myeloid leukemia (CML) will be diagnosed in 2010, representing approximately 11 % of all leukemias (Jemal et al. 2010). The median age of diagnosis reported in 2003-2007 was 65 years of age (Altekruse et al. 2010). The etiology of CML remains unclear; evidence is lacking demonstrating hereditary influence. Individuals who have been exposed to ionizing radiation or benzene are at an increase risk of developing CML (Corso et al. 1995). Other risk factors which have been evaluated include smoking, benzene, and magnetic field exposure (Bjork et al. 2001; Hayes et al. 1997; Kheifets et al. 1997). To date, these are all inconclusive in correlating exposure to acquisition of CML. A recent M.D. Anderson study suggests that adulthood obesity and occupational exposure to agricultural chemicals increase CML risk (Strom et al. 2009).

Original languageEnglish (US)
Title of host publicationHematologic Cancers
Subtitle of host publicationFrom Molecular Pathobiology to Targeted Therapeutics
PublisherSpringer Netherlands
Pages277-314
Number of pages38
ISBN (Electronic)9789400750289
ISBN (Print)9789400750272
DOIs
StatePublished - Jan 1 2012

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