Chronic myelogenous leukemia. Development of blast crisis with both lymphoid and myeloid features

Keith M Skubitz, P. R. Craddock, Daniel J Weisdorf, J. E. Niedel, Tucker W LeBien, J. H. Kersey, R. D. Brunning, J. L. Parkin, P. J. Flynn, Dale E Hammerschmidt

Research output: Contribution to journalArticlepeer-review

Abstract

A 50-year-old man had chronic myelogenous leukemia and entered a blast crisis that was both morphologically and histochemically lymphoid. The blasts contained terminal deoxyribonucleotidyl transferase and expressed lymphoblastic leukemia-associated antigen. He rapidly entered remission with vincristine sulfate and prednisone therapy. Nevertheless, his blasts displayed a marker generally considered unique to myeloid cells: they selectively bound the granulocyte chemotaxin N-formyl-Met-Leu-Phe. In addition, some cells contained granules resembling those of basophils or mast cells. Such mixed myeloid-lymphoid features in chronic myelogenous leukemia blast cells may reflect malignant transformation of a stem cell capable of both myeloid and lymphoid differentiation, or they may reflect the dedifferentiation as a feature of malignant change.

Original languageEnglish (US)
Pages (from-to)2957-2960
Number of pages4
JournalJournal of the American Medical Association
Volume250
Issue number21
DOIs
StatePublished - Dec 1 1983

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