Chronic Myelogenous Leukemia: Development of Blast Crisis With Both Lymphoid and Myeloid Features

Keith M Skubitz; Philip R. Craddock; Daniel J Weisdorf; James E. Niedel; Tucker W LeBien; John H. Kersey; Richard D. Brunning; Janet L. Parkin; Patrick J. Flynn; Dale E Hammerschmidt

doi:10.1001/jama.1983.03340210055025

Chronic Myelogenous Leukemia: Development of Blast Crisis With Both Lymphoid and Myeloid Features

Keith M Skubitz, Philip R. Craddock, Daniel J Weisdorf, James E. Niedel, Tucker W LeBien, John H. Kersey, Richard D. Brunning, Janet L. Parkin, Patrick J. Flynn, Dale E Hammerschmidt

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Abstract

A 50-year-old man had chronic myelogenous leukemia and entered a blast crisis that was both morphologically and histochemically lymphoid. The blasts contained terminal deoxyribonucleotidyl transferase and expressed lymphoblastic leukemia-associated antigen. He rapidly entered remission with vincristine sulfate and prednisone therapy. Nevertheless, his blasts displayed a marker generally considered unique to myeloid cells: they selectively bound the granulocyte chemotaxin N-formyl-Met-Leu-Phe. In addition, some cells contained granules resembling those of basophils or mast cells. Such mixed myeloid-lymphoid features in chronic myelogenous leukemia blast cells may reflect malignant transformation of a stem cell capable of both myeloid and lymphoid differentiation, or they may reflect the dedifferentiation as a feature of malignant change.

Original language	English (US)
Pages (from-to)	2957-2960
Number of pages	4
Journal	JAMA: The Journal of the American Medical Association
Volume	250
Issue number	21
DOIs	https://doi.org/10.1001/jama.1983.03340210055025
State	Published - Dec 2 1983

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Skubitz, K. M., Craddock, P. R., Weisdorf, D. J., Niedel, J. E., LeBien, T. W., Kersey, J. H., Brunning, R. D., Parkin, J. L., Flynn, P. J., & Hammerschmidt, D. E. (1983). Chronic Myelogenous Leukemia: Development of Blast Crisis With Both Lymphoid and Myeloid Features. JAMA: The Journal of the American Medical Association, 250(21), 2957-2960. https://doi.org/10.1001/jama.1983.03340210055025

Skubitz, KM, Craddock, PR, Weisdorf, DJ, Niedel, JE, LeBien, TW, Kersey, JH, Brunning, RD, Parkin, JL, Flynn, PJ & Hammerschmidt, DE 1983, 'Chronic Myelogenous Leukemia: Development of Blast Crisis With Both Lymphoid and Myeloid Features', JAMA: The Journal of the American Medical Association, vol. 250, no. 21, pp. 2957-2960. https://doi.org/10.1001/jama.1983.03340210055025

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title = "Chronic Myelogenous Leukemia: Development of Blast Crisis With Both Lymphoid and Myeloid Features",

abstract = "A 50-year-old man had chronic myelogenous leukemia and entered a blast crisis that was both morphologically and histochemically lymphoid. The blasts contained terminal deoxyribonucleotidyl transferase and expressed lymphoblastic leukemia-associated antigen. He rapidly entered remission with vincristine sulfate and prednisone therapy. Nevertheless, his blasts displayed a marker generally considered unique to myeloid cells: they selectively bound the granulocyte chemotaxin N-formyl-Met-Leu-Phe. In addition, some cells contained granules resembling those of basophils or mast cells. Such mixed myeloid-lymphoid features in chronic myelogenous leukemia blast cells may reflect malignant transformation of a stem cell capable of both myeloid and lymphoid differentiation, or they may reflect the dedifferentiation as a feature of malignant change.",

author = "Skubitz, {Keith M} and Craddock, {Philip R.} and Weisdorf, {Daniel J} and Niedel, {James E.} and LeBien, {Tucker W} and Kersey, {John H.} and Brunning, {Richard D.} and Parkin, {Janet L.} and Flynn, {Patrick J.} and Hammerschmidt, {Dale E}",

year = "1983",

month = dec,

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doi = "10.1001/jama.1983.03340210055025",

language = "English (US)",

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T2 - Development of Blast Crisis With Both Lymphoid and Myeloid Features

AU - Skubitz, Keith M

AU - Craddock, Philip R.

AU - Weisdorf, Daniel J

AU - Niedel, James E.

AU - LeBien, Tucker W

AU - Kersey, John H.

AU - Brunning, Richard D.

AU - Parkin, Janet L.

AU - Flynn, Patrick J.

AU - Hammerschmidt, Dale E

PY - 1983/12/2

Y1 - 1983/12/2

N2 - A 50-year-old man had chronic myelogenous leukemia and entered a blast crisis that was both morphologically and histochemically lymphoid. The blasts contained terminal deoxyribonucleotidyl transferase and expressed lymphoblastic leukemia-associated antigen. He rapidly entered remission with vincristine sulfate and prednisone therapy. Nevertheless, his blasts displayed a marker generally considered unique to myeloid cells: they selectively bound the granulocyte chemotaxin N-formyl-Met-Leu-Phe. In addition, some cells contained granules resembling those of basophils or mast cells. Such mixed myeloid-lymphoid features in chronic myelogenous leukemia blast cells may reflect malignant transformation of a stem cell capable of both myeloid and lymphoid differentiation, or they may reflect the dedifferentiation as a feature of malignant change.

AB - A 50-year-old man had chronic myelogenous leukemia and entered a blast crisis that was both morphologically and histochemically lymphoid. The blasts contained terminal deoxyribonucleotidyl transferase and expressed lymphoblastic leukemia-associated antigen. He rapidly entered remission with vincristine sulfate and prednisone therapy. Nevertheless, his blasts displayed a marker generally considered unique to myeloid cells: they selectively bound the granulocyte chemotaxin N-formyl-Met-Leu-Phe. In addition, some cells contained granules resembling those of basophils or mast cells. Such mixed myeloid-lymphoid features in chronic myelogenous leukemia blast cells may reflect malignant transformation of a stem cell capable of both myeloid and lymphoid differentiation, or they may reflect the dedifferentiation as a feature of malignant change.

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Chronic Myelogenous Leukemia: Development of Blast Crisis With Both Lymphoid and Myeloid Features

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