Chronic Myelogenous Leukemia: Development of Blast Crisis With Both Lymphoid and Myeloid Features

Keith M Skubitz, Philip R. Craddock, Daniel J Weisdorf, James E. Niedel, Tucker W LeBien, John H. Kersey, Richard D. Brunning, Janet L. Parkin, Patrick J. Flynn, Dale E Hammerschmidt

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A 50-year-old man had chronic myelogenous leukemia and entered a blast crisis that was both morphologically and histochemically lymphoid. The blasts contained terminal deoxyribonucleotidyl transferase and expressed lymphoblastic leukemia-associated antigen. He rapidly entered remission with vincristine sulfate and prednisone therapy. Nevertheless, his blasts displayed a marker generally considered unique to myeloid cells: they selectively bound the granulocyte chemotaxin N-formyl-Met-Leu-Phe. In addition, some cells contained granules resembling those of basophils or mast cells. Such mixed myeloid-lymphoid features in chronic myelogenous leukemia blast cells may reflect malignant transformation of a stem cell capable of both myeloid and lymphoid differentiation, or they may reflect the dedifferentiation as a feature of malignant change.

Original languageEnglish (US)
Pages (from-to)2957-2960
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume250
Issue number21
DOIs
StatePublished - Dec 2 1983

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