Chronic lung injury: Basic features and clinical relevance

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter describes basic features and pathophysiological processes rele- vant for chronic lung injury and its clinical manifestations. Acute and chronic lung injury are not distinct and separate entities, and many of the inflammatory processes, mediators, and mechanisms discussed in the con- text of acute injury in preceding chapters are also relevant for pulmonary remodeling, repair, and fibrosis. This chapter describes pathophysiological pathways contributing to lung injury and its progression to chronic patho- logy, including generalized cellular responses to stress and pulmonary inflammatory responses and defense mechanisms. Also described are med- iators and factors important in lung injury and fibroproliferation (additional discussion of mediators thought to play important roles in chronic pulmon- ary injury and fibroproliferative responses is provided in Chapter 6). In addition to covering the basic pathophysiology of chronic lung injury and fibroproliferation, this chapter also discusses related clinical disease. A variety of chronic obstructive pulmonary diseases contain prominent components of chronic lung injury and fibrosis. Two representative examples of such diseases (idiopathic pulmonary fibrosis and silicosis) are discussed to illustrate common clinical manifestations of chronic injury, abnormal remodeling, and fibroproliferation. Therapeutic interventions relevant for chronic lung disease and injury are detailed later in this book.

Original languageEnglish (US)
Title of host publicationLung Injury
Subtitle of host publicationMechanisms, Pathophysiology, and Therapy
PublisherCRC Press
Pages151-173
Number of pages23
ISBN (Electronic)9780203025642
ISBN (Print)9780824757939
StatePublished - Jan 1 2005

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Lung Injury
Fibrosis
Silicosis
Lung
Idiopathic Pulmonary Fibrosis
Acute Lung Injury
Wounds and Injuries
Chronic Obstructive Pulmonary Disease
Lung Diseases
Chronic Disease
Pathology

Cite this

Perlman, D. M., Bitterman, P. B., & Wendt, C. H. (2005). Chronic lung injury: Basic features and clinical relevance. In Lung Injury: Mechanisms, Pathophysiology, and Therapy (pp. 151-173). CRC Press.

Chronic lung injury : Basic features and clinical relevance. / Perlman, David M; Bitterman, Peter B; Wendt, Christine H.

Lung Injury: Mechanisms, Pathophysiology, and Therapy. CRC Press, 2005. p. 151-173.

Research output: Chapter in Book/Report/Conference proceedingChapter

Perlman, DM, Bitterman, PB & Wendt, CH 2005, Chronic lung injury: Basic features and clinical relevance. in Lung Injury: Mechanisms, Pathophysiology, and Therapy. CRC Press, pp. 151-173.
Perlman DM, Bitterman PB, Wendt CH. Chronic lung injury: Basic features and clinical relevance. In Lung Injury: Mechanisms, Pathophysiology, and Therapy. CRC Press. 2005. p. 151-173
Perlman, David M ; Bitterman, Peter B ; Wendt, Christine H. / Chronic lung injury : Basic features and clinical relevance. Lung Injury: Mechanisms, Pathophysiology, and Therapy. CRC Press, 2005. pp. 151-173
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