Chronic inflammatory demyelinating polyneuropathy disease activity status: Recommendations for clinical research standards and use in clinical practice

Kenneth C. Gorson, Ivo N. Van Schaik, Ingemar S.J. Merkies, Richard A. Lewis, Richard J. Barohn, Carol L. Koski, David R. Cornblath, Richard A.C. Hughes, Angelika F. Hahn, Mona Baumgarten, Jonathan Goldstein, Jonathan Katz, Michael Graves, Gareth Parry, Pieter A. Van Doorn

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Defining long-term outcomes in chronic inflammatory demyelinating polyneuropathy (CIDP) has been complicated by varying definitions of treatment response and differing scales measuring impairment or disability. An expert panel was convened to devise a CIDP Disease Activity Status (CDAS) and to classify long-term outcome by applying it to 106 patients with a consensus diagnosis of CIDP. Sixty of these cases were graded blindly by three independent reviewers to assess inter-rater reliability. The mean duration of follow-up was 6.4 years (range, 3 months-23 years). Eleven percent of patients were classified as cured (stable examination and off treatment for ≥5 years), 20% were in remission (stable and off treatment for <5 years), 44% had stable active disease but required ongoing therapy for at least 1 year, 7% were improving after recent initiation of therapy, and 18% had unstable active disease (treatment naïve or treatment refractory). Excellent inter-rater reliability was observed (kappa scores: 0.93-0.97; p < 0.0001). The CDAS is considered a simple and reproducible tool to classify patients with CIDP according to disease activity and treatment status that can be applied easily in practice and potentially to select patients for clinical trials.

Original languageEnglish (US)
Pages (from-to)326-333
Number of pages8
JournalJournal of the Peripheral Nervous System
Volume15
Issue number4
DOIs
StatePublished - Dec 1 2010

Keywords

  • CIDP
  • IVIg
  • disease activity
  • immune therapy
  • neuropathy
  • treatment

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