Chronic exercise training alters kinetic properties of rat skeletal muscle and myocardial lactate dehydrogenase

Li L. Ji, Frederick W. Stratman, Henry A. Lardy

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

10 weeks of treadmill running dramatically altered the kinetic properties of lactate dehydrogenase (EC 1.1.1.27) in skeletal muscle and myocardium in the rat. These changes, including Vmax, Km and optimal concentrations for pymvate and lactate, indicate that exercise training induces the formation of H-isozyme in skeletal muscle and M-isozyme in the heart and represent metabolic adaptations of these tissues to chronic aerobic exercise.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalFEBS Letters
Volume208
Issue number2
DOIs
StatePublished - Nov 24 1986

Keywords

  • Exercise training Lactate dehydrogenase Kinetic property Isoenzyme (Skeletal muscle Myocardium)

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