Chronic Demyelinating Polyneuropathies

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Purpose of Review: This article reviews the chronic demyelinating neuropathies, with a focus on the diagnosis and treatment of immune-mediated neuropathies and the features that can help differentiate immune-mediated neuropathies from other chronic demyelinating peripheral nerve conditions. Recent Findings: Advances in clinical phenotyping and outcomes assessment have enabled neurologists to improve disease recognition, treatment, and disease monitoring. Our understanding of the immunopathogenesis of demyelinating neuropathies is evolving. Identification of new antibodies and recognition that node of Ranvier dysfunction may be an early pathogenic feature may herald further diagnostic and treatment advancements. Summary: The chronic demyelinating polyneuropathies are heterogeneous. The clinical and diagnostic features are sometimes overlapping, and the specific disorders are variable in pathogenesis, treatment, and prognosis. This heterogeneity underscores the importance of achieving diagnostic accuracy and implementing disease-specific treatment approaches.

Original languageEnglish (US)
Pages (from-to)1310-1331
Number of pages22
JournalCONTINUUM Lifelong Learning in Neurology
Volume23
Issue number5, Peripheral Nerve and Motor Neuron Disorders
DOIs
StatePublished - Oct 1 2017
Externally publishedYes

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