Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum

Marek Schwendt; Matthew C. Hearing; Ronald E. See; Jacqueline F. McGinty

doi:10.1097/WNR.0b013e328240507a

Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum

Marek Schwendt, Matthew C. Hearing, Ronald E. See, Jacqueline F. McGinty

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Neuroadaptations affecting dopamine transmission within the prefrontal cortex and striatum are thought to underlie relapse to cocaine seeking after extended periods of abstinence. Regulator of G-protein signaling 4 (RGS4) is a forebrain-enriched protein known to be dynamically regulated by dopamine receptors in response to acute psychostimulant administration. In this report, chronic noncontingent (cocaine binge) or response-contingent (self-administration) delivery of cocaine followed by 2-3 weeks of abstinence resulted in a decrease of RGS4 mRNA in the dorsal striatum and prefrontal cortex. Furthermore, re-exposure to the cocaine-associated context after abstinence renewed the drug seeking and restored the levels of RGS4 mRNA to control values. Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking.

Original language	English (US)
Pages (from-to)	1261-1265
Number of pages	5
Journal	Neuroreport
Volume	18
Issue number	12
DOIs	https://doi.org/10.1097/WNR.0b013e328240507a
State	Published - Aug 2007
Externally published	Yes

Keywords

Abstinence
Addiction
Cocaine
G-protein
In-situ hybridization
Relapse

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/WNR.0b013e328240507a

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title = "Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum",

abstract = "Neuroadaptations affecting dopamine transmission within the prefrontal cortex and striatum are thought to underlie relapse to cocaine seeking after extended periods of abstinence. Regulator of G-protein signaling 4 (RGS4) is a forebrain-enriched protein known to be dynamically regulated by dopamine receptors in response to acute psychostimulant administration. In this report, chronic noncontingent (cocaine binge) or response-contingent (self-administration) delivery of cocaine followed by 2-3 weeks of abstinence resulted in a decrease of RGS4 mRNA in the dorsal striatum and prefrontal cortex. Furthermore, re-exposure to the cocaine-associated context after abstinence renewed the drug seeking and restored the levels of RGS4 mRNA to control values. Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking.",

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T1 - Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum

AU - Schwendt, Marek

AU - Hearing, Matthew C.

AU - See, Ronald E.

AU - McGinty, Jacqueline F.

PY - 2007/8

Y1 - 2007/8

N2 - Neuroadaptations affecting dopamine transmission within the prefrontal cortex and striatum are thought to underlie relapse to cocaine seeking after extended periods of abstinence. Regulator of G-protein signaling 4 (RGS4) is a forebrain-enriched protein known to be dynamically regulated by dopamine receptors in response to acute psychostimulant administration. In this report, chronic noncontingent (cocaine binge) or response-contingent (self-administration) delivery of cocaine followed by 2-3 weeks of abstinence resulted in a decrease of RGS4 mRNA in the dorsal striatum and prefrontal cortex. Furthermore, re-exposure to the cocaine-associated context after abstinence renewed the drug seeking and restored the levels of RGS4 mRNA to control values. Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking.

AB - Neuroadaptations affecting dopamine transmission within the prefrontal cortex and striatum are thought to underlie relapse to cocaine seeking after extended periods of abstinence. Regulator of G-protein signaling 4 (RGS4) is a forebrain-enriched protein known to be dynamically regulated by dopamine receptors in response to acute psychostimulant administration. In this report, chronic noncontingent (cocaine binge) or response-contingent (self-administration) delivery of cocaine followed by 2-3 weeks of abstinence resulted in a decrease of RGS4 mRNA in the dorsal striatum and prefrontal cortex. Furthermore, re-exposure to the cocaine-associated context after abstinence renewed the drug seeking and restored the levels of RGS4 mRNA to control values. Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking.

KW - Abstinence

KW - Addiction

KW - Cocaine

KW - G-protein

KW - In-situ hybridization

KW - Relapse

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ER -

Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum

Abstract

Keywords

UN SDGs

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